Thoracic Oncology: Open Trials
	Thoracic Oncology: Closed Trials
	Thoracic Oncology: Upcoming Trials
	Emphysema: Open Trials

 

Thoracic Oncology: Open Trials

Lung Cancer:  Stage I

• A Phase III study of adjuvant chemotherapy after resection of Stage 1(T2N0M0) non-small cell lung cancer
  
  
• VATS lobectomy: A feasibility study

Lung Cancer:  Stage I + II

• Phase II prospective randomized study of adjuvant chemotherapy in completely resected Stage I (T2N0M0) and II non-small cell lung cancer with a companion tumor marker evaluation (BR10)
  


• Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma
  
  
• The utility of PET in staging of patients with potentially operable non-small cell lung carcinoma
  
  
• Phase I study of decitabine-mediated induction of tumor antigen and tumor suppressor gene expression in lung cancer patients
  

Lung Cancer:  Stage II + IIIa

• A phase III comparison between concurrent chemotherapy plus radiotherapy, and concurrent chemotherapy plus radiotherapy followed by surgical resection for stage IIIa (N2) non-small cell lung cancer
  
  
• Pre-resection minimally invasive surgical restaging of Stage III (mediastinal node positive) non-small cell lung cancer
  
  
• A prospective study of the prognostic significance of occult metastases in the patient with resectable non-small cell lung carcinoma

Lung Cancer:  Stage Ib,II, IIIa

• Intergroup S9900: A Randomized Phase III trial of preoperative chemotherapy (paclitaxel + carboplatin) + surgery versus surgery alone in patients with early stage or resectable NSCLC

Metastatic Disease

• Phase I study of isolated lung perfusion with paclitazel and moderate hyperthermia in patients with unresectable pulmonary malignancies

Esophageal Cancer

• no active trials at present
  
  

Thoracic Oncology: Closed Trials

Lung Cancer:  Stage I

• Phase III double-blind randomized trial of 13-cis retinoic acid (13-CRA) to prevent second primary tumors in Stage I non-small cell lung cancer Video assisted wedge resection (VAR) and radiotherapy for high risk T1 non-small cell lung cancer: A phase II study

Lung Cancer:  Stage II + IIIa

• Prospective randomized trial of postoperative adjuvant therapy in patients with completely resected stage II and stage IIIa non-small cell lung cancer
  
  
• Phase III trial of surgical resection and chemotherapy (carboplatin and taxol) with or without adjuvant radiotherapy for mediastinoscopy negative but thoracotomy positive N2 Stage IIIa non-small cell lung cancer
  
  
• Phase II intergroup trial for superior sulcus lung cancer(Pancoast tumor) with concurrent chemo-radiation as induction therapy

Lung Cancer:  Metastatic Disease & Malignant Pleural Effusion

• Sclerosis of pleural effusions by talc thoracoscopy versus talc slurry: A Phase III Study
  
  
• A prospective randomized trial of Bleomycin vs Doxycycline vs Talc for intrapleural treatment of malignant pleural effusion
  
  
• Randomized trial of Open vs VATS for pulmonary metastasis
  

Lung Cancer:  Thymoma

• Phase II Study of VIP (Etoposide, Ifosfamide and Cisplatin)in the Treatment of Invasive Thymoma

Lung Cancer:  Esophageal Cancer

• Thoracoscopic staging for esophageal cancer
  
  
• A prospective randomized phase III trial comparing trimodality therapy to surgery alone for esophageal cancer

Thoracic Oncology: Upcoming Trials

Emphysema: Open Trials

Lung Volume Reduction Surgery

• Multicenter randomized clinical trial on Lung Volume Reduction Surgery
  
  
• Canadian Lung Volume Reduction Study

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