Video-assisted wedge resection (VAR) and radiotherapy for high risk T1 non-small cell lung cancer: A phase II study

Originating Group

CALGB 9335

P.I.: Dr. Hani Shennib

Participating Groups

Objectives

1. To determine the feasibility of treating patients with cardiopulmonary dysfunction and T1 peripheral NSCLC by video-assisted throacoscopic resection (VAR) and radiotherapy
2. To describe the incidence of locoregional recurrence among high risk patients with T1 peripheral non-small cell lung cancer treated by video-assisted wedge resection (VAR) and radiotherapy
3. To describe survival and disease-free survival in this patient group
4. To determine the technical feasibility of achieving a complete resection with VAR
5. To describe the rate of conversion to open thoracotomy
6. To describe the short-term and long-term complications associated with VAR
7. To describe the toxicity associated with adjuvant radiotherapy after VAR

Eligibility

1. Single, peripheral T1 lung cancer or suspected cancer
2. Pulmonary dysfunction (FEV1.0 <40% predicted, DLCO<50% predicted, VO2 max <15ml/kg/min., PaCO2 >45mm Hg., O2 requirement)
3. Lesions accessible for VAR resection
4. No metastatic or N2 disease (by CT scan, >1cm.)
5. No concomitant malignancy
6. No prior chest radiotherapy
7. Performance status 0-2
8. Weight loss <= 10% in past 6 months
9. Bronchoscopy: negative

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