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Lönn, U, Myers, T, Peterzén, B, Carnstam, B, Hubbert,
L, Lindström, L, Wårdell, K, Frazier, OH, Jarvik, R, Ahn, H.
Linköping Heart Centre, Sweden, Texas Heart Institute, and Jarvik
Heart Inc.
Purpose and background: The Jarvik 2000 Heart is designed
for long term left ventricular assist. This study aimed to evaluate
the level of hemodynamic support provided by this pump in an animal
model with acute heart failure.
Methods: Five calves were used. Heart failure was induced
by progressively ligation of the LAD combined with a continues
infusion of Esmolol. The pump was turned on and hemodynamic measurement
was obtained at different pump settings ranging from 8000 to 12000
RPM.
Results: CI, LAP and systemic arterial blood pressure
improved significantly with a pump speed over 9000 RPM. Pulse
pressure narrowed by 64 %, PAP remained unchanged. Other hemodynamic
parameters as heart rate, SVR, PVR and CVP remained unchanged.
Conclusion: The Jarvik 2000 Heart can provide a level
of cardiac output support that normalises the CI and LAP while
maintaining some arterial pressure pulsatility during acute heart
failure.
Systemic perfusion is increased while the left heart is unloaded.
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