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ABSTRACT 24
A NOVEL THERMOREGULATORY SYSTEM ATTENUATES MYOCARDIAL
INJURY IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS SURGERY
Nahum Nesher, Tamir Wolf, Miriam David, Ram
Sharoni, Gil Bolotin, Reuven Pizov, Gideon Uretzky
The Department of Cardiothoracic Surgery, Carmel Medical Center,
Technion-Israel-Institute of Technology, Haifa, Israel
Peri-operative hypothermia is associated with a variety of adverse
events. This study assessed the efficacy of a novel thermoregulation
technology used during coronary artery bypass (CABG) surgery.
CABG surgery patients were randomized into two groups: Allon
thermoregulation (AT, n=40) and routine thermal care (RTC, n=20),
and warmed perioperatively with/without the new device respectively.
AT used patients rectal (core) temperature as input data to maintain
water temperature in a circulating garment at a 37°C. Temperature,
patient hemodynamics, and cardiac specific Troponin I (cTnI) were
assessed throughout the peri-operative period.
Core temperatures were higher in the AT group at all time points.
Cardiac index (CI; L/min) was higher in the AT group: 2.5±0.5,
2.6±0.5*, 3.2±0.6*, 3.3±0.5*, 3.1±0.7 at the respective time points,
compared to the RTC group, 2.3±0.6, 2.1±0.2, 2.6±0.7, 2.7±0.7,
2.7±0.7, (*P<0.05). Systemic vascular resistance (SVR;
(dyne*sec)/cm5) was lower in AT patients. CTnI levels
were lower in AT patients throughout the post CPB period, indicative
of a lesser degree of ischemic damage in these patients.
Maintenance of peri-operative normothermia can be achieved efficiently
using the new thermoregulatory system. The beneficial effects
of such a strategy include reduced SVR, elevated CI, and attenuation
of myocardial injury as assessed by cTnI.
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