ABSTRACT 81

THE MPACT OF OFF PUMP CABG TO THE HEART AND BRAIN

Munetaka Masuda, Ryuji Tominaga, Shigeki Morita, Hisataka Yasui
Kashu University Hospital, Fukuoka, Japan

Background:  We examined perioperative changes of objective markers (creatine phosphate-MB (CK-MB) and Troponin T (TnT) for myocardial cell injury, brain natriuretic peptide (BNP) for heart failure, and S-100 protein and neuron specific enolase (NSE) for brain cell injury) to evaluate invasiveness of off pump CABG (OPCAB) compared with conventional CABG (CCAB).

Patients and Methods:  Among 217 isolated CABG cases, 28 patients were underwent OPCAB. The CK-MB, TnT, S-100 and NSE were measured subsequently up to 24 hours after the operation, and the BNP up to 2 weeks after the operation. 

Results:  The peak values of CK-MB and TnT were significantly lower in OPCAB, while BNP level increased similarly in both group with its peak value at 24 hours after the operation (average value as 246 pg/ml in OPCAB (n=12) and 312 pg/ml in CCAB (n=49)).  The S-100 and NSE increased significantly after the operation only in CCAB patients (n=12) compared with the OPCAB patients (n=10). 

Conclusion:  OPCAB is considered to be less invasive to myocardial cell and brain cell, while the impact to the heart as a whole organ is not necessarily small.