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A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery

Monday, October 5, 2015

Submitted by

Mark Ferguson

Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1413579?query=OF

Author(s)

Patrick Meybohm, Berthold Bein, Oana Brosteanu, Jochen Cremer, Matthias Gruenewald, Christian Stoppe, Mark Coburn, Gereon Schaelte, Andreas Böning, Bernd Niemann, Jan Roesner, Frank Kletzin, Ulrich Strouhal, Christian Reyher, Rita Laufenberg-Feldmann, Marion Ferner, Ivo F. Brandes, Martin Bauer, Sebastian N. Stehr, Andreas Kortgen, Maria Wittmann, Georg Baumgarten, Tanja Meyer-Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schön, Michael Sander, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Georg Fuernau, Dirk Hasenclever, and Kai Zacharowski for the RIPHeart Study Collaborators

Pts undergoing cardiac surgery requiring CPB were randomized to remote ischemic preconditioning of the upper extremity or sham intervention. The end point was combined death, MI, stroke, and acute renal failure during hospitalization, and secondary endpoints were the occurrence of any such event within 90 days. Outcomes were similar between the groups, with no treatment effects evident on multiple sub-analyses.