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Surgery Alone Versus Chemoradiotherapy Followed by Surgery for Stage I and II Esophageal Cancer: Final Analysis of Randomized Controlled Phase III Trial FFCD 9901

Tuesday, July 1, 2014

Submitted by

Mark Ferguson

Source

Source Name: Journal of Clinical Oncology

Source URL: http://jco.ascopubs.org/content/early/2014/06/24/JCO.2013.53.6532?cmpid=jco_pap_…

Author(s)

Christophe Mariette, Laetitia Dahan, Françoise Mornex, Emilie Maillard, Pascal-Alexandre Thomas, Bernard Meunier, Valérie Boige, Denis Pezet, William B. Robb, Valérie Le Brun-Ly, Jean-François Bosset, Jean-Yves Mabrut, Jean-Pierre Triboulet, Laurent Bedenne and Jean-François Seitz

In this randomized trial involving195 pts from 30 centers, pts underwent chemoradiotherapy followed by surgery or surgery alone for stage I or II esophageal cancer. The median follow-up was 94 months. 80% of pts had clinical stage II disease. R0 resection rate and 3-year survival were similar between the groups. Induction therapy was associated with an increase in operative mortality (11.1% vs 3.4%, p=0.049).