Recent Publications

Selected, recent publications are listed below. A complete list of our publications (clinical and laboratory) can be found on our TCV Surgery Research publications webpage.

Selected Clinical Publications

LaPar DJ, Yang Z, Stukenborg GJ, Peeler BB, Kern JA, Kron IL, and Ailawadi G. Outcomes of reoperative aortic valve replacement after revious sternotomy. J Thorac Cardiovasc Surg. 139:263-72, 2010.

Ailawadi G, LaPar DJ, Swenson BR, Siefert SA, Lau C, KernJA, Peeler BB, Littlewood KE and Kron IL. Model for end-stage liver disease predicts mortality for rricuspid valve surgery. Ann Thorac Surg. 87:1460-8, 2009.

LaPar DJ, Kron IL and Yang Z. Stem cell therapy for ischemic heart disease: where are we? Curr Opin Organ Transpl. 14:79-84, 2009.

Ailawadi G, Lau CL, Smith PW, Swenson BR, Hennessy SA, Kuhn CJ, Fedoruk LM, Kozower BD, Kron IL, Jones DR. Does reperfusion injury still cause significant mortality after lung transplantation? J Thorac Cardiovasc Surg  137(3):688-94, 2009.

Ailawadi G, Swenson BR, Girotti ME, Gazoni LM, Peeler BB, Kern JA, Fedoruk LM, Kron IL. Is mitral valve repair superior to replacement in elderly patients? Ann Thorac Surg  86(1):77-85, 2008.

Gazoni LM, Fedoruk LM, Kern JA, Dent JM, Reece TB, Tribble CG, Smith PW, Lisle TC, and Kron IL. A simplified approach to degenerative disease: Triangular resections of the mitral valve. Ann Thorac Surg  83:1658-1665, 2007.

Reece TB, Tribble CG, Smith RL, Singh RR, Stiles BM, Peeler BB, Kern JA, and Kron IL. Central cannulation is safe in acute aortic dissection repair. J Thorac Cardiovasc Surg 133:428-434, 2007.

Singh RR, Warren PS, Reece TB, Ellman P, Peeler BB, and Kron IL. Early repair of complete atrioventricular septal defect is safe and effective. Ann Thorac Surg 82:1598-1601, 2006.

Ellman PI, Kron IL, Alvis JS, Tache-Leon C, Maxey TS, Reece TB, et al. Acute sleep deprivation in the thoracic surgical resident does not affect operative outcomes. Ann Thorac Surg 80:60-64; discussion 64-65, 2005.

Reece TB, Tribble CG, Ellman PI, Maxey TS, Woodford RL, Dimeling GM, et al. Mitral repair is superior to replacement when associated with coronary artery disease. Ann Surg 239:671-675, 2004.

Maxey TS, Reece TB, Ellman PI, Butler PD, Kern JA, Tribble CG, et al. Coronary artery bypass with ventricular restoration is superior to coronary artery bypass alone in patients with ischemic cardiomyopathy. J Thorac Cardiovasc Surg 127:428-434, 2004.

Long SM, Tribble CG, Raymond DP, Fiser SM, Kaza AK, Kern JA, et al. Preoperative shock determines outcome for acute type A aortic dissection. Ann Thorac Surg 75:520-524, 2003.

Maxey TS, Reece TB, Ellman PI, Kern JA, Tribble CG, and Kron IL. The beating heart approach is not necessary for the Dor procedure. Ann Thorac Surg 76:1571-1574, 2003.

Kaza AK, Cope JT, Fiser SM, Long SM, Kern JA, Kron IL, et al. Elimination of fat microemboli during cardiopulmonary bypass. Ann Thorac Surg 75:555-559, 2003.

Kron IL, and Cope JT. Fate of the unligated vertical vein after surgical correction with total anomalous pulmonary venous connection in early infancy. J Thorac Cardiovasc Surg 123:829, 2002.

Cope JT, Fraser GD, Kouretas PC, and Kron IL. Complete versus partial atrioventricular canal: equal risks of repair in the modern era. Ann Surg 236:514-520, 2002.

Selected Laboratory Publications

Laubach VE, French BA, Okusa MD. Targeting of adenosine receptors in ischemia-reperfusion injury. Expert Opin Ther Targets. 15(1):103-18, 2011.

Anvari F, Sharma AK, Fernandez LG, Hranjec T, Ravid K, Kron IL and Laubach VE. Tissue-derived pro-inflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140:871-7, 2010.

Gazoni LM, Walters DM, Unger EB, Linden J, Kron IL, and Laubach VE. Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140(2):440-446, 2010.

Sharma AK, Laubach VE, Ramos SI, Zhao Y, Linden J, Kron IL, and Yang Z. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 139(2):474-482, 2010.

Laubach VE and Kron IL. Pulmonary inflammation after lung transplantation. [Review] Surgery 146(1):1-4, 2009.

Lau CL, Zhao Y, Kron IL, Stoler MH, Laubach VE, Ailawadi G, and Linden J. The Role of Adenosine A2A Receptor Signaling in Bronchiolitis Obliterans. Ann Thorac Surg 88(4):1071-8, 2009. [Link]

Sharma AK, Linden J, Kron IL, and Laubach VE*. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respiratory Research 10:58, 2009.

Lau CL, Zhao Y, Kim J, Kron IL, Sharma A, Yang Z, Laubach VE, Linden J, Ailawadi G, and Pinsky DJ. Enhanced fibrinolysis protects against lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 137(5):1241-1248, 2009.

Yang Z, Sharma AK, Linden J, Kron IL, and Laubach VE. CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury.  J Thorac Cardiovasc Surg 137(3):695-702, 2009.

Yang Z, Sharma AK, Marshall M, Kron IL, and Laubach VE. NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury. Am J Resp Cell Mol Biol  40(3):375-381, 2009.

Lisle TC, Fernandez LG, Sharma AK, Bellizzi AM, Gazoni LM, Linden J, Laubach VE, and Kron IL. Inflammatory lung injury after cardiopulmonary bypass is ameliorated by adenosine A2A receptor activation. J Thorac Cardiovasc Surg 136(5):1280-7, 2008.

Fernandez LG, Mehta CK, Kron IL, and Laubach VE. Re-initiation of compensatory lung growth after subsequent lung resection. J Thorac Cardiovasc Surg  134:1300-1305, 2007.

Sharma AK, Fernandez LG, Awad AS, Kron IL, and Laubach VE. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 293:105-113, 2007.

Gazoni LM, Tribble CG, Zhao MQ, Unger EB, Farrar RA, Ellman PI, Fernandez LG, Laubach VE, and Kron IL. Pulmonary macrophage inhibition and inhaled nitric oxide attenuate lung ischemia reperfusion injury. Ann Thorac Surg  84:247-253, 2007.

Fernandez LG, Le Cras TD, Ruiz M, Glover DK, Kron IL, and Laubach VE. Differential vascular growth in postpneumonectomy compensatory lung growth. J Thorac Cardiovasc Surg 133:309-316, 2007.

Zhao M, Fernandez LG, Doctor A, Sharma AK, Zarbock A, Tribble CG, Kron IL, and Laubach VE. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol - Lung 291:L1018-1026, 2006.

Maxey TS, Fernandez LG, Reece TB, Keeling WB, Kron IL, and Laubach VE. Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilation. Ann Thorac Surg 81:1234-1238, 2006.

Reece TB, Laubach VE, Tribble CG, Maxey TS, Ellman PI, Warren PS, Schulman AM, Linden J, Kern JA, and Kron IL. Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury. Ann Thorac Surg 79:1189-1195, 2005.

Reece TB, Ellman PI, Maxey TS, Crosby IK, Warren PS, Chong TW, et al. Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation. J Thorac Cardiovasc Surg 129:1137-1143, 2005.

Le Cras TD, Fernandez LG, Pastura PA, and Laubach VE. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol 98(3):1140-1148, 2005.

Ellman PI, Alvis JS, Tache-Leon C, Singh R, Reece TB, Kern JA, et al. Hyperoxic ventilation exacerbates lung reperfusion injury. J Thorac Cardiovasc Surg 130:1440, 2005.

Maxey TS, Enelow RI, Gaston B, Kron IL, Laubach VE, and Doctor A. Tumor necrosis factor-alpha from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg 127:541-547, 2004.

Kaza AK, Kron IL, Leuwerke SM, Tribble CG, and Laubach VE. Keratinocyte growth factor enhances post-pneumonectomy lung growth by alveolar proliferation. Circulation 106:I120-124, 2002.

Fiser SM, Tribble CG, Long SM, Kaza AK, Cope JT, Laubach VE, et al. Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response. J Thorac Cardiovasc Surg 121:1069-1075, 2001.