Clinical Epidemiology

JANS Article

Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years

November 29, 2023 | Aristotle ProtopapasGold Commentor

An important free-access report on the PARTNER 3 trial that discusses the TAVI-first policy in patietns with Society of Thoracic Surgeons Predicted Risk of Mortality risk less than 4% ( mean of 1.9%). The calls...

JANS Article

Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years

November 29, 2023 | Aristotle ProtopapasGold Commentor

An important free-access report on the PARTNER 3 trial that discusses the TAVI-first policy in patietns with Society of Thoracic Surgeons Predicted Risk of Mortality risk less than 4% (...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Long Term Health Related Quality of Life After Acute Type B Aortic Dissection: A Cross Sectional Survey Study

September 12, 2023 | Aristotle ProtopapasGold Commentor

This free-access report raises a number of research questions in light of a relatively unsatisfactory response of 55 percent that may reflect unrecorded deaths and should be addressed in future...

JANS Article

Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes

August 31, 2023 | Aristotle ProtopapasGold Commentor

This is an open access genomic study of carotid atheroma in Viennese patients with a useful extensive discussion on potential translational value of the signature of calcification, juxtaposed to sonographic...

JANS Article

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

October 21, 2021 | Aristotle ProtopapasGold Commentor

A large randomised double-blinded trial reporting a considerable benefit ( 0.79 HR with very small p and supporting confidence intervals) of the Boehringer SGLPT-2 inhibitor regardless of presence of formal...

JANS Article

Timing of Coronary Artery Bypass Grafting After Acute Myocardial Infarction May Not Influence Mortality and Readmissions

June 15, 2021 | Aristotle ProtopapasGold Commentor

Fascinating confirmation of null hypotheses including bleeding complications and survival in a Pennsylvanian cohort study, despite the easily predictable previous PCI, hock, and IABP prevalence in the emergency group. The...

JANS Article

Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD

June 11, 2021 | Aristotle ProtopapasGold Commentor

A useful detailed review (or state-of-the-art article) on revascularisation in extracardiac vascular stenoocclusive atheromatosis.

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JANS Article

Has the Time Come for Regionalization of Surgery for Acute Type A Dissection?

May 11, 2021 | Aristotle ProtopapasGold Commentor

The updated version of an expert viewpoint on resources for management of acute aortic syndrome in the United States is presented. The esteemed authors advance the position of positive volume–outcome...

JANS Article

Extended Screening Guidelines for the Diagnosis of Abdominal Aortic Aneurysm

January 10, 2021 | Aristotle ProtopapasGold Commentor

An interesting retrospective study on the efficacy of the the US screening program for aortic aneurysmal disease in the abdomen. The discussion on the detective importance of clinical examination being...

JANS Article

COVID‐19: The Rising Cost of Cardiac Surgery and Disease

December 4, 2020 | Aristotle ProtopapasGold Commentor

A brief and readable editorial on the United Kingdom prespective on the global impact of the pandemic to the delivery of cardiovascular care, attempting a semi-quantitative economic appraisal of the...

JANS Article

Rivaroxaban in Patients With Atrial Fibrillation and a Bioprosthetic Mitral Valve

November 28, 2020 | Aristotle ProtopapasGold Commentor

A large RCT with results somewhat supportive of considering a NOAC in the place of warfarin for post operative surgical patients. The study will be weighed against healthcare economical aspects....

JANS Article

Commentary: Lack of Screening Makes Primary Prevention Most Effective to Reduce the Mortality of Aortic Dissection

November 28, 2020 | Aristotle ProtopapasGold Commentor

A relatively recent, open-access, brief viewpoint on the utility of screening for thoracic aortic pathologies. Although the negative opinion expressed by the author may not be universally accepted, a debate...

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