Coronary Disease - Other

JANS Article

A Promising Heart Drug Fails, Challenging a Long-Held Theory of Disease

September 10, 2026 | Vincent SierGold Contributor

Novo Nordisk reported that the ZEUS study, which involved more than 6,300 patients with heart disease or advanced kidney disease, failed to show a benefit for ziltivekimab vs placebo. Ziltivekimab lowered interleukin-6 and C-reactive protein,...

JANS Article

A Promising Heart Drug Fails, Challenging a Long-Held Theory of Disease

September 10, 2026 | Vincent SierGold Contributor

Novo Nordisk reported that the ZEUS study, which involved more than 6,300 patients with heart disease or advanced kidney disease, failed to show a benefit for ziltivekimab vs placebo. Ziltivekimab...

JANS Article

Cardiac Shockwave Therapy in Addition to CABG Improves Myocardial Function in Ischemic Heart Failure: The CAST-HF Trial

June 27, 2024 | Mateo Marin-Cuartas

This study evaluated the outcomes after the use of cardiac shockwave therapy (SWT) combined with coronary artery bypass surgery (CABG) in patients with reduced left ventricular ejection fraction (LVEF) due...

JANS Article

Anomalous Aortic Origin of a Coronary Artery

June 20, 2024 | Jo Chikwe

The prevalence of anomalous aortic origin of a coronary artery is 0.4 percent to 0.8 percent. The decision to operate and choice of procedure can be challenging. This invited expert...

JANS Article

Mechanical Circulatory Support in Cardiogenic Shock — Persistence and Progress

May 18, 2024 | Aristotle ProtopapasGold Commentor

This article presents a succinct but comprehensive expert viewpoint on support in cardiogenic shock using the manuscript of the DanGer trial on promising results of Impella in a highly selected...

JANS Article

Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self

April 19, 2022 | Aristotle ProtopapasGold Commentor

Interesting manuscript on the immunology of coronary atheroma, with tanslational potential in therapies and prevention of ischaemic heart disease.

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JANS Article

Registry for Acute Coronary Events in Nigeria (RACE-Nigeria): Clinical Characterization, Management, and Outcome

December 25, 2021 | Emily FarkasBronze Contributor

The rising burden of CAD in low- and middle-income countries like Nigeria is a result of the epidemiological transition from communicable to non- communicable diseases. The system of care for...

JANS Article

Minimally invasive coronary bypass surgery with bilateral internal thoracic arteries: Early outcomes and angiographic patency

November 15, 2021 | Aristotle ProtopapasGold Commentor

Interesting in its candour mini-series of partial arterial revascularisation by left thoracotomy. The perioperative graft failure is delt in some detail.

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JANS Article

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

November 9, 2021 | Aristotle ProtopapasGold Commentor

A good-size Terumo-sponsored RCT that is set to impact on decisions to discontinue DAPT early after PCI with absorbable stent, a change that will somehow decrease the surgical risk of...

JANS Article

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

October 21, 2021 | Aristotle ProtopapasGold Commentor

A large randomised double-blinded trial reporting a considerable benefit ( 0.79 HR with very small p and supporting confidence intervals) of the Boehringer SGLPT-2 inhibitor regardless of presence of formal...

JANS Article

Timing of Coronary Artery Bypass Grafting After Acute Myocardial Infarction May Not Influence Mortality and Readmissions

June 15, 2021 | Aristotle ProtopapasGold Commentor

Fascinating confirmation of null hypotheses including bleeding complications and survival in a Pennsylvanian cohort study, despite the easily predictable previous PCI, hock, and IABP prevalence in the emergency group. The...

JANS Article

New-Onset Postoperative Atrial Fibrillation Impact on 5-Year Clinical Outcomes and Costs

May 27, 2021 | Aristotle ProtopapasGold Commentor

This month’s update on the economical and general aspects of the ROOBY-FS trial. The conclusion (on no impact of de novo post-CABG AF on the incidence of stroke nor the...

JANS Article

Aspirin-Free Strategies in ACS: Is It the Drug or the Stent?

February 21, 2021 | Aristotle ProtopapasGold Commentor

An editorial that may herald the decrease in aspirinization and the rise of ticagrelor monotherapy in Percutaneous stenting of coronary arteries. There might be a peripheral relevance to the group...

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