Five-Year Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Women: A Systematic Review and Meta-Analysis 

A systematic review and meta-analysis of six randomized controlled trials examined five-year outcomes comparing transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR) in 3,094 women with aortic stenosis (1,587 TAVR, 1,507 SAVR). The primary outcome, a composite of all-cause mortality or disabling stroke, showed no significant difference between groups. Meta-regression found no association between clinical covariates and outcomes. Trial sequential analysis confirmed adequate sample size but not a definitive treatment effect. While TAVR shows one-year advantages in women, five-year outcomes are equivalent. The authors conclude that future studies require sex-specific reporting to inform personalized treatment strategies.