Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma Is an Independent Predictor of Early, Extrathoracic, Multisite Recurrence and of Poor Postrecurrence Survival

This single institution retrospective study evaluated the relationship of adenocarcinoma subtype to long-term survival after resection of stage I lung cancer.  Patients with solid-predominant tumors experienced recurrences earlier, more often in distant sites, and more often in multiple locations.  This subtype was also independently associated with worse post-recurrence survival.