This article summarizes the most important issues and recommendations regarding the anatomy and physiology of tetralogy-like lesions, including diagnosis prior to medical, interventional, or surgical intervention; the timing and types of interventions; management of high-risk patients; and the need for future interventions in a subset of patients. The full versions of the original guidelines are reprinted in the supplement, providing a more comprehensive overview and enabling a more detailed approach to tetralogy and its variants.