This study reports on initial experiences with the da Vinci single-port system. The authors retrospectively reviewed patients with an anterior mediastinal mass who underwent surgery using the da Vinci single-port system via a subxiphoid approach between October 2020 and April 2024. A total of 14 patients were included, all of whom underwent complete resection without conversion to multiport or open surgery. No complications were reported following surgery, and the da Vinci single-port system was deemed safe and feasible. However, further experience and technological advancements are necessary to expand its indications in thoracic surgery.