A pooled analysis of outcomes from two randomized trials involving SBRT or surgery for operable patients with clinical early stage NSCLC was performed. The number of patients was small (58 total) and the follow-up was a median of 35-40 mos. Overall 3-year survival was better in the SBRT group (95% vs 79%; p=0.037) whereas recurrence free survival di
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Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials
May 20, 2015
May 19, 2015
Pts with suspected lung cancer underwent sampling of normal-appearingbronchial epithelial cells in the main bronchi, unrelated to the suspected tumor. Gene expression was analyzed and classified. Classification for cancer was about 75% accurate.
Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection
May 17, 2015
The most recent WHO classification for lung adenocarcinoma is based on the predominant histologic subtype in the resected tumor. Several studies have validated the use of this classification system for prognostic purposes, but predicting response to adjuvant chemotherapy has not yet been tested.
May 17, 2015
In this population-based cohort study with 1044 patients who underwent esophagectomy for esophageal cancer between 1987 and 2010 in Sweden, the researchers found that a higher number of lymph nodes removed did not affect mortality in any specific stage.
May 8, 2015
Targeting specific genetic changes in cancer cells offers patients personalized therapy for their tumors. The number of identified abnormalities is rapidly increasing, and determining whether they represent driver mutations or background noise is increasingly difficult. The IBM Watson supercomputer will be used by 10 US cancer centers to identify a
Effects of Extended Pleurectomy and Decortication on Quality of Life and Pulmonary Function in Patients With Malignant Pleural Mesothelioma
April 30, 2015
This prospective study evaluated QOL and lung function after extended pleurectomy/decortication (EPD) for mesothelioma in 36 patients. Patients with performance status (PS) 0 experienced little or no improvement in QOL but did have a significant decrease in lung function (FVC, FEV1, TLC, DLCO). Patients with PS 1-2 experienced improved QOL and no i
Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas
April 23, 2015
The authors reviewed patients with small resected stage I lung adenocarcinoma to determine the frequency of tumor cells spreading through airway spaces (STAS) and their relationship to recurrent cancer. Nearly 40% of patients had tumor cells in the airways beyond the edge of the main tumor. In patients undergoing parenchymal-sparing operations, the
April 21, 2015
This video presents a single-port VATS right upper lobectomy for stage Ia NSCLC in an 81-year-old patient.
April 16, 2015
This feature length documentary takes an in-depth look at uniportal VATS, the relatively new procedure created by Diego Gonzalez Rivas. The film chronicles the development of the procedure, and follows Dr. Gonzalez Rivas as he introduces the minimally invasive technique to hospitals from the UK to China.
April 13, 2015
This retrospective case-control study involving 1852 Hodgkin lymphoma 5-year survivors found that radiation to the heart valves tend to increase the risk for clinically significant valvular heart disease. The rate increased 3.1-fold in patients receiving 31-35 Gy and 11.8-fold in those who received > 40 Gy.