Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism

This randomized, double-blind study assigned pts with acute VTE who were initially treated with heparin to endoxaban or warfarin.   The drugs were equivalent in preventing recurrent VTE, and endoxaban was associated with a lower risk of bleeding (p=0.004).  Pts who had RV dysfunction associated with PE had a substantially reduced risk of recurrent VTE with endoxaban.