A Randomized Trial of Genotype-Guided Dosing of Warfarin

Submitted by: Erica CurcioGold Contributor

Source: New England Journal of Medicine
Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1311386?query=OF

Keywords:

Author(s): M Pirmohamed and others for the EU-PACT Group

455 patients with a-fib or VTE were randomized to pharmacogenetic-directed warfarin therapy for the first 5 days or a 3-day loading regimen.  Genotype-based dosing resulted in a 10% higher rate of being in the therapeutic range, a shorter time to reach a therapeutic INR, and fewer instances of excessive anticoagulation. 

Add Comments

ADD TO PLAYLIST

Related Content