The aim of this genetic study conducted on a large lung transplant population is to demonstrate the relationship between some genetic variants of IL-17 and IL-23 and the risk of development of chronic allograft rejection. This association could lead to new ways of prevention and treatment.
Genetic variation in interleukin-17 receptor A is functionally associated with chronic rejection after lung transplantation
Submitted by: Erica Curcio
Source: Journal of Heart and Lung Transplantation
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Author(s): David Ruttens, Els Wauters, Michal Kiciński, Stijn E. Verleden, Elly Vandermeulen, Robin Vos, Dirk E. Van Raemdonck, Tim S. Nawrot, Diether Lambrechts, Geert M. Verleden, Bart M. Vanaudenaerde