Predictors of Nodal Metastases for Clinical T2N0 Esophageal Adenocarcinoma

Barbetta and colleagues retrospectively reviewed outcomes for 80 patients with T2N0 esophageal adenocarcinoma, staged by endoscopic ultrasound (EUS) and treated by surgery alone. EUS staging was inaccurate in the majority of patients, and final pathologic staging found nodal disease in 35% of patients. Vascular invasion was identified as an independent predictor of nodal involvement, and the authors suggest that its utility as a marker to select patients for induction therapy should be further explored.