Heart Failure - Nonischemic

JANS Article

Mapping Human Cardiac Sarcoidosis by Single Nuclear and Spatial Profiling

September 30, 2022 | Aristotle ProtopapasGold Commentor

This editorial describes the evolving pathway of diagnosing a disease that is predicted to augment the indication for orthotopic cardiac transplantation. Cardiac involvement of sarcoidosis accounts for the majority of deaths in sarcoidosis patients, so...

JANS Article

Five-Year Follow-Up after Transcatheter Repair of Secondary Mitral Regurgitation

June 1, 2023 | Aristotle ProtopapasGold Commentor

This five-year follow-up of a large randomized controlled clinical trial on outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation, as compared with outcomes after maximal doses of guideline-directed medical...

JANS Article

Mapping Human Cardiac Sarcoidosis by Single Nuclear and Spatial Profiling

September 30, 2022 | Aristotle ProtopapasGold Commentor

This editorial describes the evolving pathway of diagnosing a disease that is predicted to augment the indication for orthotopic cardiac transplantation. Cardiac involvement of sarcoidosis accounts for the majority of...

JANS Article

Effects of Atrial Fibrillation on the Human Ventricle

February 24, 2022 | Aristotle ProtopapasGold Commentor

Interesting study of hypertrophied human cardiomyocytes

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JANS Article

The Right Ventricle During Veno-Venous Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: Can We Protect the Injured Ventricle?

January 21, 2022 | Aristotle ProtopapasGold Commentor

An editorial with some interest for the cardiothoracic surgeon, in particular the awareness of changes in the right vantricle during ECMO support , mostly drawn from the recent Covid experiences,...

JANS Article

Postmarket Experience With HeartMate 3 Left Ventricular Assist Device: 30-Day Outcomes From the ELEVATE Registry

January 30, 2019 | Claire Vernon

Garbade and colleagues compared outcomes reported during the European Conformity (CE) Mark clinical trial of the HeartMate 3 left ventricular assist device (LVAD) to outcomes for patients treated since the...

JANS Article

Right Ventricular Pulmonary Coupling as a Therapeutic Target in Heart Failure With Preserved Ejection Fraction

January 18, 2019 | Aristotle ProtopapasGold Commentor

A good attempt to shed some light into the somewhat challenging concept of heart failure with preserved ejection fraction, on the occasion of a small randomized controlled trial on albuterol.

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JANS Article

Six-Month Outcomes After Treatment of Advanced Heart Failure With a Full Magnetically Levitated Continuous Flow Left Ventricular Assist Device: Report From the ELEVATE Registry

October 23, 2018 | Wei-Guo Ma

A post-market study (ELEVATE registry) of the fully magnetically levitated continuous flow HeartMate III left ventricular assist device (LVAD) found no pump thrombosis in 463 patients in Europe and Kazakhstan....

JANS Article

Desmin and Cardiac Disease: An Unfolding Story

May 15, 2018 | Aristotle ProtopapasGold Commentor

A sober editorial on a murine model of induced cardiac failure, which highlights the challenges of translating animal omics to humans

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JANS Article

Two-Year Outcomes With a Magnetically Levitated Cardiac Pump in Heart Failure

March 12, 2018 | Aristotle ProtopapasGold Commentor

An interesting two-year report from the MOMENTUM 3 randomized controlled trial comparison of HeartMate 3 and II, the analysis performed by Abbott. Although stroke and reoperation were clearly lower with...

JANS Article

Effects of Older Donor Age and Cold Ischemic Time on Long-Term Outcomes of Heart Transplantation

March 1, 2018 | Aristotle ProtopapasGold Commentor

A 16-year retrospective analysis of cardiac transplantation outcomes, recommending cold ischemic times of less than two hours for older donors.

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JANS Article

Selective Implantation of Durable Left Ventricular Assist Devices as Primary Therapy for Refractory Cardiogenic Shock

February 28, 2018 | Aristotle ProtopapasGold Commentor

A retrospective Mount Sinai small series on selective emergent implantation of long-term ventricular assist devices in cardiogenic shock. It challenges the traditional concept of short-term stabilisation with ECMO or short-term...

JANS Article

Paradigm Shift for Treatment of Atrial Fibrillation in Heart Failure

February 2, 2018 | Aristotle ProtopapasGold Commentor

An editorial from an influential source discussing the recent robust results of the CASTLE-AF RCT trial. It is likely that interventions for atrial fibrillation will be boosted by these results,...

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