Lung - Basic Science

JANS Article

Osimertinib with or without Chemotherapy in EGFR-Mutated Advanced NSCLC

November 10, 2023 | Aristotle ProtopapasGold Commentor

A manuscript that wil certainly be discussed in lung MDT! The thought of a RCT in these earlier stages may be already in the mind of the sponsors… The authors do not report synergic side...

JANS Article

Osimertinib with or without Chemotherapy in EGFR-Mutated Advanced NSCLC

November 10, 2023 | Aristotle ProtopapasGold Commentor

A manuscript that wil certainly be discussed in lung MDT! The thought of a RCT in these earlier stages may be already in the mind of the sponsors… The authors...

JANS Article

The Right Ventricle During Veno-Venous Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: Can We Protect the Injured Ventricle?

January 21, 2022 | Aristotle ProtopapasGold Commentor

An editorial with some interest for the cardiothoracic surgeon, in particular the awareness of changes in the right vantricle during ECMO support , mostly drawn from the recent Covid experiences,...

JANS Article

Tobacco Smoking and Somatic Mutations in Human Bronchial Epithelium

February 3, 2020 | Mark FergusonBronze Contributor

This interesting study compared bronchial epithelial mutation burden, the primary source of new lung cancers, among nonsmokers, former smokers, and current smokers. Smoking typically adds 1,000 to 10,000 mutations per...

JANS Article

Long-Term Follow-Up of Ground-Glass Nodules After 5 Years of Stability

August 20, 2019 | Aristotle ProtopapasGold Commentor

Interesting follow-up study of 208 pulmonary ground -glass opacities in 160 subjects, with a yield of three adenocardinomas.

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JANS Article

What’s New in Pulmonary Transplantation: Finding the Right Lung for Every Patient

February 20, 2016 | Aristotle ProtopapasGold Commentor

A succinct editorial from a British academic transplant surgeon. It discusses the need for stratifying the utilization of donor lungs based on recent and previous retrospective papers from North American...

JANS Article

Integrating Tumor and Stromal Gene Expression Signatures With Clinical Indices for Survival Stratification of Early-Stage Non–Small Cell Lung Cancer

August 26, 2015 | Marcelo Jimenez

Investigators from Stanford developed a nine-gene expression predictor for survival outcome in early-stage nonsquamous NSCLC. They developed and validated a quantitative real-time polymerase chain reaction assay easily applicable to routinely...

JANS Article

miR-Test: A Blood Test for Lung Cancer Early Detection

March 21, 2015 | Marcelo Jimenez

Concerns remain about the definition of a high risk population who can benefit from low-dose computed tomography screening programs. In this paper, the authors present a promising tool to optimize...

JANS Article

Objective Measurement and Clinical Significance of TILs in Non–Small Cell Lung Cancer

March 12, 2015 | Marcelo Jimenez

Samples from tissue microarrays of 552 NSCLC patients were analyzed to measure the levels of 3 different tumor-infiltrating lymphocytes (TILs): CD3, CD8, and CD20. An elevated level of CD3 or...

JANS Article

Untreatable Tuberculosis: Is Surgery the Answer?

March 1, 2015 | Marcelo Jimenez

The increasing prevalence of multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) in some countries is alarming. When few therapeutic options remain, old procedures need to be re-evaluated based on evidence, specially,...

JANS Article

Aerogenous Metastases: A Potential Game Changer in the Diagnosis and Management of Primary Lung Adenocarcinoma

December 10, 2014 | Marcelo Jimenez

This interesting article summarizes the evidence from clinical, radiologic and pathologic investigations that lung cancer, specifically adenocarcinoma, may metastasize through the airways, defined as discontinuous spread of cancer cells from...

JANS Article

The centenary (2015) of the transfer factor for carbon monoxide (TLCO): Marie Krogh’s legacy

December 2, 2014 | Mark FergusonBronze Contributor

This is an interesting historical vignette describing the discovery of transfer factor (TLCO, DLCO) and its subsequent importance in pulmonary physiology and cardiorthoracic risk assessment.

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JANS Article

Transcriptomic Architecture of the Adjacent Airway Field Cancerization in Non–Small Cell Lung Cancer

April 14, 2014 | Marcelo Jimenez

In this promising investigation, authors have found changes associated with airway cancerization in large airways in lung cancer patients, while these changes are absent in cancer-free smokers. And in addition,...

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