Peripheral Vascular

JANS Article

Paclitaxel coated devices (PCD) used in the treatment of peripheral arterial disease: update to previous MHRA guidance on use. Where indicated, PCD can be considered as a treatment option for both critical limb ischaemia (CLI) and intermittent claudicatio

February 12, 2024 | Aristotle ProtopapasGold Commentor

Level IV evidence from the Broitish government in the most prominent debate on cardiovascular pharmacology of the last few years: Since December 2018, the paclitaxel coated devices have been scrutinised for safety . This week’s...

JANS Article

Expanding Endovascular Therapy in Trauma

December 15, 2023 | Aristotle ProtopapasGold Commentor

A condensed, granular and yet comprehensive discussion on a small retrospective series on mostly non-iatrogenic trauma of the subclavian and axillary arteries treated mostly by stenting. Professor Veller’s viewpoint is...

JANS Article

The VASCUNExplanT Project: An International Study Assessing Open Surgical Conversion of Failed Non-Infected Endovascular Aortic Aneurysm Repair

November 15, 2023 | Aristotle ProtopapasGold Commentor

A number of interesting points are raised in this relatively short manuscript. The authors conclude that there is an unmet need for robust independent international registry data from the manufacturers...

JANS Article

Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes

August 31, 2023 | Aristotle ProtopapasGold Commentor

This is an open access genomic study of carotid atheroma in Viennese patients with a useful extensive discussion on potential translational value of the signature of calcification, juxtaposed to sonographic...

JANS Article

Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia

November 14, 2022 | Aristotle ProtopapasGold Commentor

Quite possibly, this manuscript is projected to have the highest impact on patient care and industry for the immediate future. It provides an unusually clear narrative, and findings of a...

JANS Article

Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression

July 11, 2022 | Aristotle ProtopapasGold Commentor

There could be some translational value for cardiovascular surgical practice from this prospective cardiovascular health study. The mechanistic link warrants further investigation and interpretation.

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JANS Article

Treatment of Carotid Stenosis in Asymptomatic, Nonoctogenarian, Standard Risk Patients with Stenting Versus Endarterectomy Trials

July 1, 2022 | Aristotle ProtopapasGold Commentor

This is an interesting, well-written account of pooled results of two medium-size RCTs . It would be interesting to see a third arm of optimum medical therapy in follow-up studies...

JANS Article

Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term

March 30, 2022 | Aristotle ProtopapasGold Commentor

Interesting case-control study on variations of aortovascular compliance

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JANS Article

Abelacimab for Prevention of Venous Thromboembolism

August 14, 2021 | Aristotle ProtopapasGold Commentor

Interesting multi-center RCT that paves the way for potential paradigm shifts in antithrombotic modulation. The abcence of symptomatic pulmonary embolism warrants further investigation…

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JANS Article

Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD

June 11, 2021 | Aristotle ProtopapasGold Commentor

A useful detailed review (or state-of-the-art article) on revascularisation in extracardiac vascular stenoocclusive atheromatosis.

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JANS Article

Editor’s Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis

January 16, 2021 | Aristotle ProtopapasGold Commentor

A recent European consensus paper. Relatively easily read, and favouring meta-analyses over randomised trials. The bulk of the manuscript is of interest to all healthcare providers. The chapters 2.8.1 and...

JANS Article

Simulation Based Training and Assessment in Open Vascular Surgery: A Systematic Review

December 20, 2020 | Aristotle ProtopapasGold Commentor

A scholarly metanalytic review on training by surgical simulators. The authors submit that low-fidelity is acceptable, balancing affordable basic inanimate models against the higher cost (and ethics) of zootomy and...

JANS Article

Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease

December 10, 2020 | Aristotle ProtopapasGold Commentor

An ad hoc interim analysis pursuant to previous publications raising concerns on Paclitaxel DCS in chronic critical and not-critical lower limb ischaemia. The short manuscript requires careful reading to form...

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