Pharmacology

JANS Article

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

January 23, 2024 | Aristotle ProtopapasGold Commentor

This is a useful manuscript on long-term follow up confirming the findings of the five-year study, with regards to superior survival on CRT than on ICD. The authors discuss the limitations of the chronology of...

JANS Article

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

January 23, 2024 | Aristotle ProtopapasGold Commentor

This is a useful manuscript on long-term follow up confirming the findings of the five-year study, with regards to superior survival on CRT than on ICD. The authors discuss the...

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association

June 23, 2022 | Aristotle ProtopapasGold Commentor

This scientific statement is a granular contribution to a major cardiovascular issue, illuminating nuances of the “generally recognized as safe” (GRAS) FDA designation. One would expect the relevant Thoracic Associations...

JANS Article

Assessment of Preoperative Opioid Use Prevalence and Clinical Outcomes in Pulmonary Resection

June 10, 2021 | Mark FergusonBronze Contributor

Over 30% of lung resection patients in the STS Database had prior exposure to opioid use. They experienced longer length of postoperative stay, more frequent visits to the ED, and...

JANS Article

Aspirin-Free Strategies in ACS: Is It the Drug or the Stent?

February 21, 2021 | Aristotle ProtopapasGold Commentor

An editorial that may herald the decrease in aspirinization and the rise of ticagrelor monotherapy in Percutaneous stenting of coronary arteries. There might be a peripheral relevance to the group...

JANS Article

Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation

January 30, 2021 | Aristotle ProtopapasGold Commentor

A Canadian multi-centre RCT of immediate baloon-cryoablation of the pulmonary veins: the intervention was compared to the relevant standard of pharmacological care. The target population was treatment-naive sufferers of de...

JANS Article

Editor’s Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis

January 16, 2021 | Aristotle ProtopapasGold Commentor

A recent European consensus paper. Relatively easily read, and favouring meta-analyses over randomised trials. The bulk of the manuscript is of interest to all healthcare providers. The chapters 2.8.1 and...

JANS Article

Rivaroxaban in Patients With Atrial Fibrillation and a Bioprosthetic Mitral Valve

November 28, 2020 | Aristotle ProtopapasGold Commentor

A large RCT with results somewhat supportive of considering a NOAC in the place of warfarin for post operative surgical patients. The study will be weighed against healthcare economical aspects....

JANS Article

Neoadjuvant and Adjuvant Immunotherapy: Opening New Horizons for Patients With Early-Stage Non-small Cell Lung Cancer

November 21, 2020 | Aristotle ProtopapasGold Commentor

A scholarly and sober narrative review on , as the authors state, a ‘ hot topic’ that is already being debated in Multidisciplinary Meetings and Lung Cnacer Boards.

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JANS Article

Cardiac Myosin Activation With Omecamtiv Mecarbil in Systolic Heart Failure

November 17, 2020 | Aristotle ProtopapasGold Commentor

A latge RCT of the first myosin inhibitor in severe chronic heart failure: somewhat difficult to interpret results, as deaths were slightly higher in the intervention group while there was...

JANS Article

Early Rhythm-Control Therapy in Patients With Atrial Fibrillation

October 1, 2020 | Aristotle ProtopapasGold Commentor

Death from cardiovascular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome was reduced (P=0.005) by early pharmacogical or inteventional ablation for fast response-atrial fibrillation in...

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