Pharmacology

JANS Article

Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association

June 23, 2022 | Aristotle ProtopapasGold Commentor

This scientific statement is a granular contribution to a major cardiovascular issue, illuminating nuances of the “generally recognized as safe” (GRAS) FDA designation. One would expect the relevant Thoracic Associations in North America and Europe...

JANS Article

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

January 23, 2024 | Aristotle ProtopapasGold Commentor

This is a useful manuscript on long-term follow up confirming the findings of the five-year study, with regards to superior survival on CRT than on ICD. The authors discuss the...

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association

June 23, 2022 | Aristotle ProtopapasGold Commentor

This scientific statement is a granular contribution to a major cardiovascular issue, illuminating nuances of the “generally recognized as safe” (GRAS) FDA designation. One would expect the relevant Thoracic Associations...

JANS Article

Testing Epinephrine for Out-of-Hospital Cardiac Arrest

August 31, 2018 | Aristotle ProtopapasGold Commentor

A balanced editorial discussing the relevant RCT from Britain. The esteemed authors are correct to highlight the overall discouraging survival from out-of-hospital cardiac arrest WITHOUT NEUROLOGICAL DEFICIT. What does need...

JANS Article

Anticoagulation and Antiplatelet Strategies After On-X Mechanical Aortic Valve Replacement

June 17, 2018 | Tom C. NguyenBronze Contributor

Controversial and revisited topic of dual-antiplatelet therapy (DAPT) (aspirin and clopidogrel) versus low dose warfarin after On-X mechanical aortic valve replacement. There were two arms to the study: low and...

JANS Article

Doing More With Less: Hand-Powered Ultralow-Cost Paper Centrifuge

May 22, 2018 | Mark FergusonBronze Contributor

A centrifuge made of paper and string and powered by hand can separate plasma from whole blood in 90 seconds and permit the diagnosis of malaria in 15 minuntes at...

JANS Article

Cardiovascular Metabolomics

May 4, 2018 | Aristotle ProtopapasGold Commentor

A detailed well-referenced update on cardiovascular biomarkers, included in a compendium issue of the periodical.

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JANS Article

Retrieval of Severe Acute Respiratory Failure Patients on Extracorporeal Membrane Oxygenation: Any Impact on Their Outcomes?

May 3, 2018 | Aristotle ProtopapasGold Commentor

The latest on portable venovenous ECMO in a cohort in which half of the subjects died after a resource-intensive treatment. The results of the relevant EOLIA trial are keenly awaited.

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JANS Article

Preoperative Oral Carbohydrate Load Versus Placebo in Major Elective Abdominal Surgery (PROCY)

March 21, 2018 | Mark FergusonBronze Contributor

One of the more contentious issues in Enhanced Recovery After Surgery (ERAS) programs is the role of preoperative carbohydrate loading. This randomized trial demonstrated less need for insulin for treating...

JANS Article

Differences and Similarities in Risk Factors for Postoperative Acute Kidney Injury Between Younger and Older Adults Undergoing Cardiac Surgery

January 24, 2018 | Aristotle ProtopapasGold Commentor

A well executed study on an important problem in cardiac surgery that merits careful reading, as no one-sentence conclusion can be adequately gleaned.

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JANS Article

2017 EACTS Guidelines on Perioperative Medication in Adult Cardiac Surgery

January 17, 2018 | Claire Vernon

The new EACTS Guidelines on perioperative medication in adult cardiac surgery address antithrombotic management, atrial fibrillation, renin–angiotensin–aldosterone system inhibitors, beta-blockers, dyslipidaemia, ulcer prevention and steroids, antibiotic prophylaxis, anaesthesia and postoperative...

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