Physiology

JANS Article

Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics

May 30, 2024 | Aristotle ProtopapasGold Commentor

This paper details an under-development animal model to study the vascular pathology of vein grafts in a variation of the initial Carrel canine bypass experiment. The possible findings on detrimental effects of hydrostatic distention, if...

JANS Article

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

August 30, 2024 | Aristotle ProtopapasGold Commentor

An experiment that may find some translational value in the drive to elucidate inflammation as a target for controlling cardiovascular disease. Columbia University has on this occasion focused on elucidating...

JANS Article

Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics

May 30, 2024 | Aristotle ProtopapasGold Commentor

This paper details an under-development animal model to study the vascular pathology of vein grafts in a variation of the initial Carrel canine bypass experiment. The possible findings on detrimental...

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how...

JANS Article

Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts

September 20, 2022 | Aristotle ProtopapasGold Commentor

Plasma metabolomic profiles were examined to determine differences in social determinants of health between Black and white women. This observational study paves the groundwork for further investigation of social disparity...

JANS Article

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases

May 23, 2020 | Aristotle ProtopapasGold Commentor

a readable review that advances the position that Adolphe Quetelet’s formula is now clinically obsolete

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JANS Article

A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse

May 11, 2020 | Aristotle ProtopapasGold Commentor

Interesting hypothesis in a rodent model of myxomatous degeneration.

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JANS Article

Treatment for Severe Acute Respiratory Distress Syndrome From COVID-19

March 24, 2020 | Aristotle ProtopapasGold Commentor

A succinct comment with a wealth of up-to-date references vis-a-vis the SARS-CoV-2 pandemic.

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JANS Article

Eating Chocolate to Improve Muscle Health and Walking Ability in Patients With Peripheral Artery Disease

February 20, 2020 | Aristotle ProtopapasGold Commentor

The authors revisit the older, somewhat misinterpreted hypothesis of cocoa and vasodilation. The title may again be misinterpreted by the general media as an encouragement to gorge on HIGH CALORIE,...

JANS Article

Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability

December 4, 2019 | Aristotle ProtopapasGold Commentor

Well-presented Canadian prospective study juxtaposing a combination of Wells scoring and dimers to the imaging gold standard. It was particularly fascinating to read the referenced assertion that: …..the prevalence of...

JANS Article

Commentary: The dream of predicting postoperative atrial fibrillation: Are we getting closer?

November 14, 2019 | Aristotle ProtopapasGold Commentor

Interesting succinct note on a major issue, noting a possible association between cardiopulmonary bypass and this common complication.

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JANS Article

Evaluation of the INSPIRE Trial and Its Implications for Lung Transplantation With Normothermic Portable Ex Vivo Lung Perfusion

October 30, 2019 | Aristotle ProtopapasGold Commentor

A balanced appraisal of last year’s manuscript from the Lancet Group on a relatively novel portable Organ Care System for donor lungs. The analysis of the technical complications, especially organ...

JANS Article

Peripheral Vasoconstriction During Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease

October 26, 2019 | Aristotle ProtopapasGold Commentor

Interesting clinicolaboratory experiment: Any translational value for the coronary surgeon and the cardiologist remains to be seen, especially regarding the risk stratification and prioritization for urgent (inpatient) revascularisation. Also, the...

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