Physiology

JANS Article

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

August 30, 2024 | Aristotle ProtopapasGold Commentor

An experiment that may find some translational value in the drive to elucidate inflammation as a target for controlling cardiovascular disease. Columbia University has on this occasion focused on elucidating by flow cytometry the nuances...

JANS Article

Dapagliflozin and Acute Kidney Injury Following, Cardiac Surgery: A Randomized Clinical Trial

September 3, 2026 | Vincent SierGold Contributor

In this Dutch multicenter, double-blind trial, 784 adults undergoing elective cardiac surgery received dapagliflozin 10 mg (n=392) or placebo (n=392), starting one day preoperatively for four doses. Acute kidney injury...

Video

Stable Sternotomies Without Wound Complications: An Interview With Klaudiusz Stoklosa

July 24, 2026 | Klaudiusz Stoklosa…

This interview highlights safer sternotomies and reducing wound complications. At the 2026 American Association for Thoracic Surgery (AATS) Annual Meeting, thoracic surgeon and CTSNet Editor-in-Chief Joel Dunning spoke with Dr....

JANS Article

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

August 30, 2024 | Aristotle ProtopapasGold Commentor

An experiment that may find some translational value in the drive to elucidate inflammation as a target for controlling cardiovascular disease. Columbia University has on this occasion focused on elucidating...

JANS Article

Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics

May 30, 2024 | Aristotle ProtopapasGold Commentor

This paper details an under-development animal model to study the vascular pathology of vein grafts in a variation of the initial Carrel canine bypass experiment. The possible findings on detrimental...

JANS Article

Evaluation of the INSPIRE Trial and Its Implications for Lung Transplantation With Normothermic Portable Ex Vivo Lung Perfusion

October 30, 2019 | Aristotle ProtopapasGold Commentor

A balanced appraisal of last year’s manuscript from the Lancet Group on a relatively novel portable Organ Care System for donor lungs. The analysis of the technical complications, especially organ...

JANS Article

Peripheral Vasoconstriction During Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease

October 26, 2019 | Aristotle ProtopapasGold Commentor

Interesting clinicolaboratory experiment: Any translational value for the coronary surgeon and the cardiologist remains to be seen, especially regarding the risk stratification and prioritization for urgent (inpatient) revascularisation. Also, the...

JANS Article

Exercise is Medicine in Oncology: Engaging Clinicians to Help Patients Move Through Cancer

October 17, 2019 | Mark FergusonBronze Contributor

A coalition of international organizations dealing with cancer and sports medicine have updated recommendations, stating that exercise may help prevent cancer and can improve survival in patients with cancer. Methods...

JANS Article

The Right Ventricle During Selective Lung Ventilation for Thoracic Surgery

October 14, 2019 | Aristotle ProtopapasGold Commentor

A narrative review offering an intensivists’ viewpoint on specific cardiovascular sequela of double-lumen anaesthesia for pulmonary resections (and by extension, implantation of donor lungs) and other cardiothoracic and vascular operations.

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JANS Article

The Right Ventricular Response to Lung Resection

October 14, 2019 | Aristotle ProtopapasGold Commentor

An extremely interesting research question abutting cardiac physiology, and a manuscript that may generate future additional clinical research.

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JANS Article

Measuring Chordae Tension During Transapical Neochordae Implantation: Toward Understanding Objective Consequences of Mitral Valve Repair

October 8, 2019 | Aristotle ProtopapasGold Commentor

An interesting pilot experiment on attempting to quantify the optimum disposition of neochordae in transapical intervention for severe mitral regurgitation.

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JANS Article

Does Atelectasis Cause Fever After Surgery? Putting a Damper on Dogma

September 22, 2019 | Mark FergusonBronze Contributor

The authors point out that randomized trials of incentive spirometry have failed to mitigate early postoperative fevers, traditionally attributed to atelectasis. They propose that an immune response triggered by injured...

JANS Article

Improving Heart Muscle Function

August 31, 2019 | Mark FergusonBronze Contributor

The growth and replication of cardiomyocytes derived from stem cells is insufficient to permit regeneration of functioning heart tissue. In this study, the authors used stem cell-derived epicardial cells to...

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