Physiology

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how to target the behavior of...

JANS Article

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

August 30, 2024 | Aristotle ProtopapasGold Commentor

An experiment that may find some translational value in the drive to elucidate inflammation as a target for controlling cardiovascular disease. Columbia University has on this occasion focused on elucidating...

JANS Article

Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics

May 30, 2024 | Aristotle ProtopapasGold Commentor

This paper details an under-development animal model to study the vascular pathology of vein grafts in a variation of the initial Carrel canine bypass experiment. The possible findings on detrimental...

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how...

JANS Article

Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts

September 20, 2022 | Aristotle ProtopapasGold Commentor

Plasma metabolomic profiles were examined to determine differences in social determinants of health between Black and white women. This observational study paves the groundwork for further investigation of social disparity...

JANS Article

Exercise is Medicine in Oncology: Engaging Clinicians to Help Patients Move Through Cancer

October 17, 2019 | Mark FergusonBronze Contributor

A coalition of international organizations dealing with cancer and sports medicine have updated recommendations, stating that exercise may help prevent cancer and can improve survival in patients with cancer. Methods...

JANS Article

The Right Ventricle During Selective Lung Ventilation for Thoracic Surgery

October 14, 2019 | Aristotle ProtopapasGold Commentor

A narrative review offering an intensivists’ viewpoint on specific cardiovascular sequela of double-lumen anaesthesia for pulmonary resections (and by extension, implantation of donor lungs) and other cardiothoracic and vascular operations.

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JANS Article

The Right Ventricular Response to Lung Resection

October 14, 2019 | Aristotle ProtopapasGold Commentor

An extremely interesting research question abutting cardiac physiology, and a manuscript that may generate future additional clinical research.

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JANS Article

Measuring Chordae Tension During Transapical Neochordae Implantation: Toward Understanding Objective Consequences of Mitral Valve Repair

October 8, 2019 | Aristotle ProtopapasGold Commentor

An interesting pilot experiment on attempting to quantify the optimum disposition of neochordae in transapical intervention for severe mitral regurgitation.

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JANS Article

Does Atelectasis Cause Fever After Surgery? Putting a Damper on Dogma

September 22, 2019 | Mark FergusonBronze Contributor

The authors point out that randomized trials of incentive spirometry have failed to mitigate early postoperative fevers, traditionally attributed to atelectasis. They propose that an immune response triggered by injured...

JANS Article

Improving Heart Muscle Function

August 31, 2019 | Mark FergusonBronze Contributor

The growth and replication of cardiomyocytes derived from stem cells is insufficient to permit regeneration of functioning heart tissue. In this study, the authors used stem cell-derived epicardial cells to...

JANS Article

Commentary: Mitral Valve Repair With Left Ventricular Assist Device Implantation: Yes! But Who?

August 23, 2019 | Aristotle ProtopapasGold Commentor

Excellent and brief summary of the debate on functional mitral regurgitation on mechanical support.

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JANS Article

Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy

August 22, 2019 | Aristotle ProtopapasGold Commentor

A robust RCT that denies association of nuclear CT-defined myocardial viability and long-term benefit from surgical coronary revascularisation. It is worth following the discussion this manuscript is certain to generate..

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