Vascular - Systemic Diseases

JANS Article

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

August 30, 2024 | Aristotle Protopapas

An experiment that may find some translational value in the drive to elucidate inflammation as a target for controlling cardiovascular disease. Columbia University has on this occasion focused on elucidating by flow cytometry the nuances...

JANS Article

The VASCUNExplanT Project: An International Study Assessing Open Surgical Conversion of Failed Non-Infected Endovascular Aortic Aneurysm Repair

November 15, 2023 | Aristotle Protopapas

A number of interesting points are raised in this relatively short manuscript. The authors conclude that there is an unmet need for robust independent international registry data from the manufacturers...

JANS Article

Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes

August 31, 2023 | Aristotle Protopapas

This is an open access genomic study of carotid atheroma in Viennese patients with a useful extensive discussion on potential translational value of the signature of calcification, juxtaposed to sonographic...

JANS Article

Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia

November 14, 2022 | Aristotle Protopapas

Quite possibly, this manuscript is projected to have the highest impact on patient care and industry for the immediate future. It provides an unusually clear narrative, and findings of a...

JANS Article

Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self

April 19, 2022 | Aristotle Protopapas

Interesting manuscript on the immunology of coronary atheroma, with tanslational potential in therapies and prevention of ischaemic heart disease.

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JANS Article

Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term

March 30, 2022 | Aristotle Protopapas

Interesting case-control study on variations of aortovascular compliance

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JANS Article

Endovascular Repair of the Ascending Aorta: The Last Frontier

February 16, 2022 | Aristotle Protopapas

A useful short review accompanied by media , related to the background of the ARISE Study. The esteemed authors discuss the potential endovascular options for zone 0 for inoperable Acute...

JANS Article

Management of Abdominal Aortic Aneurysms

November 1, 2021 | Aristotle Protopapas

An extremely useful and free-access update on a major vascular entity. The ‘Areas of Uncertainty’ is a particularly useful chapter, discussing the available technology and its current supra-renal limitations and...

JANS Article

Has the Time Come for Regionalization of Surgery for Acute Type A Dissection?

May 11, 2021 | Aristotle Protopapas

The updated version of an expert viewpoint on resources for management of acute aortic syndrome in the United States is presented. The esteemed authors advance the position of positive volume–outcome...

JANS Article

Editor’s Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis

January 16, 2021 | Aristotle Protopapas

A recent European consensus paper. Relatively easily read, and favouring meta-analyses over randomised trials. The bulk of the manuscript is of interest to all healthcare providers. The chapters 2.8.1 and...

JANS Article

Reassessing the Operative Threshold for Abdominal Aortic Aneurysm Repair in the Context of COVID-19

September 7, 2020 | Aristotle Protopapas

Patients with aneurysms 7 cm or greater demonstrated a higher probability of survival when treated immediately, compared to delayed repair, for patients under 80 years of age. An interesting attempt...

JANS Article

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

May 30, 2020 | Emily Farkas

Autopsy examination of lungs from patients who died from SARS-CoV-2 infection, with comparison to the morphologic & molecular features of lungs from patients who died from ARDS secondary to influenza...

JANS Article