Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Left Main Disease According to Age

Recent percutaneous revascularization of unprotected left main disease has generated a debate about the outcomes after percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) disease. The authors in this metanalysis used four randomized control trials and 10 adjusted observational studies, which total 24,767 patients to compare PCI with CABG. Within the limitations of a meta-analysis, which includes the limitations and inherent biases of all the individual studies involved, PCI was found to be associated with a higher risk of all-cause death and repeat revascularization compared to CABG. In the elderly population, PCI and CABG appeared to have similar outcomes, but there was a higher risk of major adverse cardiac events (MACE) with PCI.