Tomoki Sakata

[Publication]

[Book Chapters]

• Sakata, T., Mazurek, R., Mavropoulos, S.A., Romeo, F.J., Ravichandran, A.J., Ishikawa, K. (2022). Assessing the Effect of Cardiac Gene Therapy Using Catheter-Based Pressure–Volume Measurement in Large Animals. In: Ishikawa, K. (eds) Cardiac Gene Therapy. Methods in Molecular Biology, vol 2573. Humana, New York, NY.

[Peer-reviewed Journals]

• Morita Y, Sakata T, Nakamura Y, Kikuchi Y, Wang J, Kaneyuki D, Kariya T, Raphael J. The Effect of Transport Manual and Mechanical Ventilation on Hemodynamics Change: Randomized Clinical Trial. Semin Cardiothorac Vasc Anesth. Published online September 24, 2025.

• Sakata T, Nakamura Y, Rajagopal K, Tchantchaleishvili V, Plestis K, Entwistle J, Bavaria J, Suri M. Infrequent Need for Temporary Mechanical Circulatory Support After Mitral Valve Surgery. Ann Thorac Surg Short Rep. 2024;3:52-56.

• Sakata T, Pfeil D, Suri M. Biventricular Dysfunction Due to Chronic Mitral Valve Regurgitation Caused by Aberrant Mitral Arcade. Ann Thorac Surg Short Rep. 2024;2(4):783-786.

• Fujii M, Okino S, Sakata T, Mogi K, Sakurai M, Takahara Y, J-PVAD registry investigators. Safety and Efficacy of Surgical Revascularization with Percutaneous Ventricular Assist Device for Acute Myocardial Infarction Complicated by Cardiogenic shock: Japanese national registry study. Artif Organs. 2025;49(3):516-524.

• Mavropoulos S, Aikawa T, Mazurek R, Sakata T, Yamada K, Watanabe K, Sunagawa G, Singleton D, Leonard K, Kariya T, Sahoo S, Ishikawa K. A Minimally-Invasive Swine Model of Chronic Kidney Disease-Associated Heart Failure. Am J Physiol Heart Circ Physiol. 2025;328(2):H260-H270.

• Mazurek R, Tharakan S, Mavropoulos S, Singleton D, Bikou O, Sakata T, Kariya T, Yamada K, Kohlbrenner E, Liang L, Ravichandran A, Watanabe S, Hajjar R, Ishikawa K. AAV delivery strategy with mechanical circulatory support for safe and efficacious cardiac gene transfer in swine. Nat Commun. 2024;15(1):10450.

• Xu Y, Korayem A, Cruz-Solbes AS, Chandel N, Sakata T, Mazurek R, Mavropoulos SA, Kariya T, Aikawa T, Yamada KP, D'Escamard V, V'Gangula B, Baker AH, Ma L, Björkegren JLM, Fuster V, Boehm M, Fish KM, Tadros R, Ishikawa K, Kovacic JC. Inhibition of endothelial to mesenchymal transition in a large animal preclinical arterio- venous fistula model leads to improved remodeling and reduced stenosis. Cardiovasc Res. 2024:cvae157.

• Sakata T, Mavropoulos S, Mazurek R, Romeo F, Ravichandran A, Kariya T, Ishikawa K. Reduction of Left Ventricular Diastolic Pressure as a Key Regulator of Infarct Coronary Flow under Mechanical LV Support. J Physiol. 2024;602:1669-1680.

• Sakata T, Kohno H, Inui T, Ikeuchi H, Shiko Y, Kawasaki Y, Suzuki S, Fujio Y, Matsumiya G. Cardioprotective Effect of Interleukin-11 against Warm Ischemia-Reperfusion Injury in A Rat Heart Donor Model. Eur J Pharmacol. 2023 Dec 15;961:176145.
• Gregory V, Isath A, Sakata T, Ishikawa K, Ohira S. Clinical Implication of Transvalvular Unloading with Venoarterial Extracorporeal Membrane Oxygenation Support in Acute Myocardial Infarction. JACC Basic Transl Sci. 2023 Sep 25;8(9):1243-1244..
• Sakata T, Miyamoto Y, Kuno T. Combining Left Main and Multivessel Coronary Artery Disease as a Revascularization Target. J Thorac Cardiovasc Surg. 2023 Apr 29:S0022-5223(23)00277-5.
• Sakata T, De La Pena C, Ohira S. Functional or Anatomical Completeness of Revascularization after Coronary Artery Bypass Grafting. Ann Thorac Surg. 2023 Apr 11:S0003-4975(23)00369-7.
• Sakata T, De La Pena C, Ohira S. Rapid-Deployment Aortic Valve Replacement : Patient Selection and Special Considerations. Vasc Health Risk Manag. 2023;19:169-180.
• Mazurek R, Kariya T, Sakata T, Mavropoulos SA, Ravichandran AJ, Romeo FJ, Yamada KP, Ishikawa K. Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading. J Cardiovasc Transl Res. 2023 Apr 6:10.1007/s12265-023-10371-z.
• Nishiori H, Sakata T, Ueda H, Matsumiya G. Intimal Tear Closure by False Lumen Stent Grafts placement for Post-dissection Thoracoabdominal Aortic Aneurysm. J Vasc Surg Cases Innov Tech. 2023;9:101157.
• Sakata T, Kuno T, Fujisaki T, Yokoyama Y, Misumida N, Sugiura S, Latib A. Selection of Vascular Closure Devices in Transcatheter Aortic Valve Replacement: Systematic Review and Network Meta-Analysis. Cardiovasc Revasc Med. 2022;11:S1553-8389(22)00709-6.
• Yokoyama Y, Sakata T, Mikami T, Kuno T, Takagi H, Sugiura T, Latib A. Vascular Access For Transcatheter Aortic Valve Replacement: A Network Meta-Analysis. J Cardiol. 2023;82:227-233.
• Romeo F, Mazurek R, Sakata T, Mavropoulos S, Ishikawa K. Device-Based Approaches Targeting Cardioprotection in Myocardial Infarction: The Expanding Armamentarium of Innovative Strategies. J Am Heart Assoc. 2022;11:e026474.
• Sakata T, Mazurek R, Mavropoulos S, Romeo F, Ravichandran A, Ishikawa K. Assessing the effect of cardiac gene therapy using pressure-volume relationship in large animals. Methods Mol Biol. 2022;2573:313-321.
• Mavropoulos SA, Yamada KP, Sakata T, Ishikawa K. Cardiac Gene Delivery in Large Animal Models: Antegrade Techniques. Methods Mol Biol. 2022;2573:147-158.
• Nishiori H, Sakata T, Matsumiya G. Right Anterior Minithoracotomy for Redo Aortic Valve Replacement After Coronary Artery Bypass Grafting with Bilateral Internal Thoracic Artery: a Case Report. J Card Surg. 2022;37:5613-5615.
• Hanazuka T, Sakata T, Ueda H, Watanabe M, Matsumiya G. Late Open Conversion After Endovascular Treatment for the Coarctation of Aorta in Adult Due to Restenosis with Thrombus. J Vasc Surg Cases Innov Tech. 2022;8:338-344.
• Nishiori H, Sakata T, Makino S, Kawakami M, Matsumiya G. Alport syndrome: A case study of chronic type A aortic dissection. J Card Surg. 2022;37:2134-2137.
• Sakata T, Mazurek R, Mavropoulos S, Romeo F, Ravichandran A, Kariya T, Ishikawa K. Left Atrial Remodeling and Dysfunction in Swine Models of Mitral Regurgitation. Am J Physiol Heart Circ Physiol. 2022;322:H914-H923.
• Sakata T, Watanabe S, Mazurek R, Mavropoulos S, Romeo F, Yamada K, Ishikawa K. Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow by Mechanical Left Ventricular Unloading in a Swine Model of Ischemic Heart Failure. Front Cardiovasc Med. 2022;8:795322.
• Uchiyama S, Sakata T (co-first), Tharakan S, Ishikawa K. Body temperature as a predictor of mortality in COVID-19. Sci Rep. 2023;13:13354.
• Hashimoto M, Mogi K, Sakurai M, Sakata T, Tani K, Takahara Y. Rupture of a dissecting thoracoabdominal aortic aneurysm due to Citrobacter freundii infection. Clin Case Rep. 2021 30;9:e04719.
• Sakata T, Mogi K, Matsuura K, Sakurai M, Shiko Y, Kawasaki Y, Matsumiya G, Takahara Y. Mid-term Functional Recovery after Tricuspid Annuloplasty Concomitant with Left-sided Valve Surgery. Gen Thorac Cardiovasc Surg. 2021;69:662-672.
• Sakata T, Mogi K, Sakurai M, Tani K, Hashimoto M, Shiko Y, Kawasaki Y, Matsumiya G, Takahara Y. Impact of Tricuspid Annuloplasty on Postoperative Changes in The Right Ventricular Systolic and Diastolic Function: A Retrospective Cohort Study. J Card Surg. 2020;35:1464-1470. 
• Sakata T, Mogi K, Sakurai M, Nomura A, Fujii M, Kaneyuki D, Matsumiya G, Takahara Y. Impact of Tricuspid Annuloplasty Concomitant with Left Heart Surgery on Right Heart Geometry and Function. J Thorac Cardiovasc Surg. 2018;156:1050-1061.
• Matsumiya G, Kohno H, Matsuura K, Sakata T, Tamura Y, Watanabe M, Ueda H. Right ventricular papillary muscle approximation for functional tricuspid regurgitation associated with severe leaflet tethering. Interact Cardiovasc Thorac Surg. 2018;26:700-702.
• Kaneyuki D, Mogi K, Sakurai M, Nomura A, Sakata T, Takahara Y. An Eight-Year Natural History of Chronic Contained Rupture With Vertebral Erosion. Ann Thorac Surg. 2018;105:e227.
• Fujii M, Sakurai M, Mogi K, Nomura A, Sakata T, Takahara Y. Multiple Spontaneous Iliac and Femoral Arteriovenous Fistulas. Ann Vasc Surg. 2018;46:367.e11-367.e13.
• Kaneyuki D, Sakata T, Nomura A, Sakurai M, Mogi K, Takahara Y. Off-pump resection of a giant inflamed epicardial cyst. Surg Case Rep. 2018;4:87.
• Kaneyuki D, Mogi K, Sakata T, Takahara Y. Surgicel® packing remnants mimicking mediastinitis after adult cardiac surgery. Interact Cardiovasc Thorac Surg. 2018;26:1035-1036.
• Sakata T, Mogi K, Sakurai M, Nomura A, Fujii M, Shimizu S, Takahara Y. Popliteal Artery Pseudoaneurysm Caused By Osteochondroma. Ann Vasc Surg. 2017;43:313e5-7
• Sakata T, Kohno H, Iwahana T, Ota S, Ishibashi-Ueda H, Kobayashi Y, Matsumiya G. Papillary Muscle Rupture in an Adolescent with No Coronary Lesions. J Heart Valve Dis. 2017;26:231-233
• Sakata T, Mogi K, Sakurai M, Nomura A, Fujii M, Shimizu S, Takahara Y. Rupture of Anterolateral Papillary Muscle due to Small Artery Occlusion. Ann Thorac Surg 2017;104:e113–114.
• Sakata T, Kohno H, Watanabe M, Tamura Y, Abe S, Inage Y, Ueda H, Matsumiya G. Implantation of HeartMate II as a Bridge to Bridge from Biventricular Support. Jpn.J. Cardiovasc. Surg. 2016;45:267-271
• Sakata T, Mogi K, Sakurai M, Nomura A, Takahara Y. Extracardiac rupture of a sinus of Valsalva aneurysm. Extracardiac rupture of a sinus of Valsalva aneurysm. J Card Surg. 2017;32:93-94.
• Sakata T, Nakaya M, Otsu M, Sunazawa T, Wakabayashi Y. Autologous Pericardial Patch Repair for Papillary Fibroelastoma on the Aortic Valve Leaflet. Tex Heart Inst J 2017;44:1-3
• Sakata T, Ueda H, Watanabe M, Kohno H, Tamura Y, Abe S, Inage Y, Ikeuchi H, Kanda T, Fujii M, Matsumiya G. Endovascular Treatment for Proximal Anastomotic Pseudoaneurysm after Total Arch Replacement in Behcet's Disease. Ann Vasc Surg. 2016;34:272.e9-12.

[Meeting Presentation (International Meeting Only)]

• Sakata T, Nakamura Y, Rajagopal K, Tchantchaleishvili V, Plestis K, Entwistle J, Bavaria J, Suri R. Infrequent Need for Temporary Mechanical Circulatory Support After Mitral Valve Surgery. 30th Congress of the International Society for Mechanical Circulatory Support. Utsunomiya, Japan, 2024.

• Rahimov D, Sakata T, Macmillan R, Pritting C, Nasher N, Rame J, Alvarez R, Rajagopal K, Entwistle J, Tchantchaleishvili V. Impact of 2018 donor heart allocation policy change on outcomes for patients on biventricular support. 30th Congress of the International Society for Mechanical Circulatory Support. Utsunomiya, Japan, 2024.

• Sakata T, Mavropoulos S, Mazurek R, Romeo F, Ravichandran A, Marx J, Kariya T, Watanabe S, Ishikawa K. Mechanical LV support lowers diastolic LV pressure and prolongs diastolic coronary flow in the infarcted artery. European Society of Cardiology Congress, Amsterdam, Netherland, 2023.

• Sakata T, Mazurek R, Mavropoulos S, Romeo F, Ravichandran A, Ishikawa K. Mechanical LV unloading mitigates increase in left atrial pressure, volume, and workload in a pig model of acute cardiogenic shock. American Association for Thoracic Surgery 103rd Annual Meeting, Los Angels, USA, 2023.
• Mazurek R, Raichandran A, Mavropoulos S, Sakata T, Ishikawa K. Cardiac AAV Gene Therapy is Enabled after Repeat Injection by Temporary Coronary Occlusions in a Pig Model of Heart Failure. American Society for Gene/Cell Therapy 26th Annual Meeting, Los Angels, USA, 2023.
• Sakata T, Mazurek R, Mavropoulos S, Romeo F, Ravichandran A, Ishikawa K. Upregulation of Left Atrial SLN and CTGF Gene Expression in Porcine Models of Mitral Regurgitation. American Association for Thoracic Surgery Mitral Conclave, New York, USA, 2023.
• Sakata T, Mazurek R, Mavropoulos S, Romeo F, Ravichandran A, Ishikawa K. Mechanical LV unloading increases coronary flow by prolonging diastolic phase. Acute Cardiac Unloading and Recovery 7th Annual Symposium, Chicago, USA, 2022.
• Sakata T, Kuno T, Fujisaki T, Yokoyama Y, Misumida N, Sugiura T, Latib A. Selection of Vascular Closure Devices in Transcatheter Aortic Valve Replacement: Systematic Review and Network Meta-Analysis. TVT 2022: Structural Heart Summit, Chicago, USA, 2022.
• Sakata T, Yamada K, Mazurek R, Mavropoulos S, Romeo F, Ishikawa K. Influence of Left Atrial Ischemia on Progression of Its Remodeling and Dysfunction in Swine Models with Ischemic and Degenerative Mitral Regurgitation. Society of Thoracic Surgeons 58th Annual Meeting, Miami, USA, 2022.
• Sakata T. Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow Improvement with Mechanical LV Unloading. Acute Cardiac Unloading and Recovery 6th Annual Symposium, Boston (virtual), USA, 2022.
• Sakata T, Mogi K, Sakurai M, Tani K, Hashimoto M, Takahara Y. Di!erences Of Right Ventricular Functional Recovery Between Therapeutic And Prophylactic Tricuspid Annuloplasty. American Association for Thoracic Surgery Mitral Conclave, New York, USA, 2019
• Sakata T, Mogi K, Sakurai M, Tani K, Hashimoto M, Takahara Y. Impact of Tricuspid Annuloplasty on Postoperative Changes of Right Ventricular Systolic and Diastolic Function. 32nd EACTS Annual Meeting, Milan, Italy, 2018
• Sakata T, Mogi K, Sakurai M, Nomura A, Fujii M, Takahara Y. Effect of Tricuspid Annuloplasty on the Improvement of Right Heart Dimensions and Function. ESC congress, Barcelona, Spain, 2017
• Sakata T, Mogi K, Sakurai M, Nomura A, Fujii M, Takahara Y. Impact of Tricuspid Annuloplasty Concomitant with Left Heart Surgery on Right Heart Geometry and Function. American Association for Thoracic Surgery Mitral Conclave, New York, USA, 2017
• Sakata T, Kohno H, Ueda H, Matsuura K, Tamura Y, Watanabe M, Fujii M, Ikeuchi H, Kanda T, Matsumiya G. Reccurent Tricuspid Regurgitation After Tricuspid Annuloplasty - Risk Factor Analysis and Effect On Right Heart Function. 25th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery, Seoul, Korea, 2017

[Research Grant]

• 2020 Apr – 2021 Mar  Grant-in-Aid for Young Scientists, Funding Agency: Japan Society for the Promotion of Science, Project number: 20244604, Title: "The protective effect of interleukin-11 on donor heart with warm ischemia", Role: PI, Amount: 4,160,000 JPY
• 2021 Mar Research Grant Abroad, Funding Agency: Japan Heart Foundation / Bayer Yakuhin, Title: "Application of circulatory assist devices to gene induction in gene therapy for heart failure", Amount: 3,000,000 JPY
• 2021 - 2022 A-CURE Research Fellowship, Funding Agency: ABIOMED Inc., Title: "Studying coronary physiology in mechanical left ventricular unloading", Amount: $100,000

[Honors and Prizes]

• 2024 30th Congress of International Society for Mechanical Circulatory Support, Traveling Fellowship Grant
• 2023  Acute Cardiac Unloading and Recovery 8th Annual Symposium, Research Merit Scholarship Award
• 2022  Acute Cardiac Unloading and Recovery 7th Annual Symposium, Best in Research Award (The highest-scored abstract in all submission)
• 2021  Acute Cardiac Unloading and Recovery 6th Annual Symposium, Research Merit Scholarship Award (Top 10 abstract)
• 2018  Chiba University Cardiovascular Surgery, Young Investigator Award 
• 2015  Chiba University Cardiovascular Surgery, Young Investigator Award