The 2025 ESC/EACTS Guidelines for the management of valvular heart disease (VHD) are an update to the 2021 version of this document. Key topics that have been updated include the central role of the Heart Team, emphasizing patient-centered decision-making; the importance of Heart Valve Centers for managing complex patients; advanced diagnostic imaging with clearly defined diagnostic criteria for specific VHD pathologies, including aortic stenosis and multiple valvular disease; and appropriate indications and timing for different interventional options for patients with VHD.