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Clinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study

Saturday, March 8, 2014

Submitted by

Mark Ferguson

Source

Source Name: Journal of Clinical Oncology

Source URL: http://jco.ascopubs.org/content/32/8/768?cmpid=jco_etoc_10March2014

Author(s)

G Sozzi, M Boeri, M Rossi, C Verri, P Suatoni, F Bravi, L Roz, D Conte, M Grassi, N Sverzellati, A Marchiano, E Negri, C La Vecchia, U Pastornio

In an effort to provide diagnostic information complementary to radiographic screening for lung cancer, the authors evaluated the diagnostic performance of plasma mRNA. The mRNA signature classifier demonstrated 87% sensitivity and 81% specificity, with a negative predictive value of 99%. In contrast, low dose CT had a sensitivity of 79% and a specificity of 81%. Combining the mRNA signature classifier and low dose CT resulted in a 5-fold decrease in false positive findings based on CT alone.