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Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

Tuesday, February 23, 2016

Submitted by

Mark Ferguson

Source

Source Name: JAMA

Source URL: http://jama.jamanetwork.com/article.aspx?articleid=2492876

Author(s)

Manu Shankar-Hari; Gary S. Phillips; Mitchell L. Levy; Christopher W. Seymour; Vincent X. Liu; Clifford S. Deutschman; Derek C. Angus; Gordon D. Rubenfeld; Mervyn Singer; for the Sepsis Definitions Task Force

This consensus effort provides a new definition for septic shock, which affects a subset of patients with sepsis. The definition requires the presence of circulatory disturbances (BP unresponsive to fluids and requiring pressors), cellular and metabolic abnormalities (serum lactate level >2 mmol/L). The presence of these criteria is associated with an increased risk of mortality compared to sepsis alone.