ALERT!

This site is not optimized for Internet Explorer 8 (or older).

Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.

Initial Surgical versus Conservative Strategies in Patients with Asymptomatic Severe Aortic Stenosis

Monday, October 19, 2015

Submitted by

Ruben Osnabrugge

Source

Source Name: Journal of the American College of Cardiology

Source URL: http://content.onlinejacc.org/article.aspx?articleID=2457337&utm_source=Silverch…

Author(s)

Tomohiko Taniguchi; Takeshi Morimoto; Hiroki Shiomi; Kenji Ando; Norio Kanamori; Koichiro Murata; Takeshi Kitai; Yuichi Kawase, Chisato Izumi; Makoto Miyake; Hirokazu Mitsuoka; Masashi Kato; Yutaka Hirano; Shintaro Matsuda; Kazuya Nagao; Tsukasa Inada; Tomoyuki Murakami; Yasuyo Takeuchi; Keiichiro Yamane; Mamoru Toyofuku; Mitsuru Ishii; Eri Minamino-Muta; Takao Kato; Moriaki Inoko; Tomoyuki Ikeda; Akihiro Komasa; Katsuhisa Ishii; Kozo Hotta; Nobuya Higashitani; Yoshihiro Kato; Yasutaka Inuzuka; Chiyo Maeda; Toshikazu Jinnai; Yuko Morikami; Ryuzo Sakata; Takeshi Kimura

The investigators in this registry study enrolled 3815 patients with asymptomatic aortic stenosis. Patients underwent either surgical aortic valve replacement (AVR) or conservative therapy. In order to increase comparability, they used propensity score matching to create two more similar groups. The cumulative 5-year incidences of all-cause death and heart failure hospitalization were significantly lower in the initial AVR group compared to the conservative group (15.4% vs. 26.4%, p=0.009 and 3.8% vs. 19.9%, p<0.001). Moreover, 41% of the patients in the conservative treatment group received AVR during follow-up. These results indicate that initial AVR in patients asymptomic severe aortic stenosis might be substantially improved by initial AVR.