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Randomized Phase II Study of the Anti-inflammatory Effect of Ghrelin During the Postoperative Period of Esophagectomy

Tuesday, July 14, 2015

Submitted by

Mark Ferguson

Source

Source Name: Annals of Surgery

Source URL: http://journals.lww.com/annalsofsurgery/Abstract/2015/08000/Randomized_Phase_II_…

Author(s)

Takata, Akihiro; Takiguchi, Shuji; Miyazaki, Yasuhiro; Miyata, Hiroshi; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Yamasaki, Makoto; Nakajima, Kiyokazu; Mori, Masaki; Kangawa, Kenji; Doki, Yuichiro

This small randomized trial evaluated the potential benefits of ghrelin, an anti-inflammatory agent, in reducing the SIRS response after esophagectomy. The ghrelin group had a reduced SIRS duration, lower CRP levels, and lower IL-6 levels compared to controls. Pulmonary complications were reduced in the ghrelin group, but other complication incidences were similar.