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Statin initiation and acute kidney injury following elective cardiovascular surgery: a population cohort study in Denmark

Monday, March 7, 2016

Submitted by

CTSNet Staff

Source

Source Name: Eur J Cardiothorac Surg

Source URL: http://ejcts.oxfordjournals.org/content/49/3/995.abstract

Author(s)

James Bradley Layton, Malene K. Hansen, Carl-Johan Jakobsen, Abhijit V. Kshirsagar, Jan J. Andreasen, Vibeke E. Hjortdal, Bodil S. Rasmussen, Ross J. Simpson, Maurice Alan Brookhart, and Christian F. Christiansen

Approximately 3800 patients who underwent elective cardiac surgery were analyzed for post-surgical acute kidney injury (AKI). AKI occurred in 21% of patients who initiated a statin within 100 days prior to surgery compared with 29% of patients without prior statin use. The adjusted relative risk for the effect of statin initiation on AKI was RR = 0.86 (95% CI: 0.74, 0.98). Thus, presurgical statin initiation is associated with a reduction in AKI risk after cardiac surgery.