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Journal and News Scan

Source: Nature Communications
Author(s): Monica E. D’Arcy, Ruth M. Pfeiffer, Marie C. Bradley, Phuc H. Hoang, Thi-Van-Trinh Tran, John P. McElderry, Mengying Li, Michael Kebede, Curt T. DellaValle, Sara Rivas, Youjin Wang, Shahinaz M. Gadalla, and Maria Teresa Landi

This article presents a large, population-based study using UK primary care data to identify comorbid conditions associated with lung cancer in never-smokers (LCINS). Across two independent data sets (CPRD-GOLD and CPRD-Aurum), the study found several inflammatory and autoimmune conditions significantly associated with an increased risk of LCINS, particularly COPD/emphysema, gastroesophageal reflux disease (GERD), gastritis, type 1 diabetes mellitus, anemia, and bronchitis. These associations persisted even after adjusting for medication use, socioeconomic status, and body mass index. This study underscores the biological plausibility of chronic inflammation as a contributing factor to the pathogenesis of LCINS. 
 
This research is of high relevance to the CTSNet global cardiothoracic surgery audience, as it informs risk stratification and screening strategies for lung cancer in patients without a history of smoking. Understanding these associations could enhance early detection and influence surgical evaluations in the growing population of LCINS patients. 

Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Author(s): Marc W. Gerdisch, Chanice Johns, Manesh Parikshak, Andrew Barksdale, Louis P. Perrault

This article describes the outcomes of adding active chest tube clearance (ATC) to enhanced recovery after cardiac surgery (ERAS) program, comparing 684 patients who underwent ATC compared to 650 patients who did not. The authors noted a 41 percent reduction in retained blood (ATC group: 8.2 percent vs non-ATC group: 4.8 percent, p<0.05), a decrease in postoperative atrial fibrillation (ATC group: 28 percent vs non-ATC group: 33 percent, p<0.05), and a statistically significant reduction in median ICU hours. This improvement was attributed to the known high incidence of clogging in chest tubes, which was improved with active chest tube clearance. The authors also correlated their outcomes with favorable improvements in resource utilization and cost savings. 

Source: The Lancet
Author(s): Torsten Doenst, Maurice Enriquez Sarano, Hristo Kirov, Tulio Caldonazo, Joanna Chikwe, Julien Dreyfus, Joseph Zacharias

Heart valve disease is a leading cause of mortality, with increasing incidence due to an aging population. Early referral to specialized heart networks is vital, as late diagnosis often leads to palliative rather than curative treatment. Geographic variations exist in diseases causes, and less than 25 percent of patients are referred for necessary interventions, partly due to perceived treatment risks. Establishing multidisciplinary heart networks can improve patient survival by tailoring treatment plans and facilitating early referrals, demonstrating that timely interventions enhance long-term outcomes for those with heart valve disease.  

Source: The Journal of Thoracic and Cardiovascular Surgery Open
Author(s): Zohaib R. Khawaja, Akalya Villenthi, Aaron S. Gilani, Benjamin I. Schachner, Gabriel E. Cambronero, Charles E. Bardawil, Timothy E. Craven, Bartlomiej R. Imielski

This study evaluated social media and online platform use among 223 randomly selected, actively practicing cardiothoracic surgeons from the American Association for Thoracic Surgery. Nearly all surgeons (99.6 percent) had a professional online presence, primarily through practice websites (99.6 percent), CTSNet (98.2 percent), LinkedIn (78.9 percent), and ResearchGate (57.4 percent). However, active engagement with general social media platforms was relatively low (42.6 percent), with X/Twitter being the most used (32.7 percent). No significant differences were observed in platform use across subspecialties, practice types, or training pathways. Notably, female surgeons and those practicing in the Southwest United States were more likely to use Facebook and Instagram. Early-career surgeons had higher overall online presence scores and were more active on X/Twitter, while mid-career surgeons favored LinkedIn. These findings highlight that while professional networking is nearly universal, broader social media engagement among cardiothoracic surgeons remains limited, offering opportunities for increased digital outreach and patient engagement. 

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): Jean-Luc A. Maigrot, David Moros, Eugene H. Blackstone, Aaron J. Weiss, Milind Y. Desai, A. Marc Gillinov, Nicholas G. Smedira

Mitral valve leaflet and subvalvular apparatus abnormalities can cause left ventricular outflow tract obstruction in the absence of septal hypertrophy. The authors discuss different techniques to address this situation, based on two key principles: modifying the effects of altered flow vortices that change the position of mitral valve leaflets with relation to the outflow tract and restoring posterior coaptation of the leaflets. The preoperative workup is detailed, including echocardiography and cardiac MRI to assess leaflet and papillary muscle anatomy. Various repair techniques are described, including anterior leaflet shortening, reduction of posterior leaflet height, papillary muscle head reorientation and partial resection, as well as mitral valve replacement when necessary. 

Source: The Journal of Thoracic and Cardiovascular Surgery Open
Author(s): Rajika Jindani, Debora Brascia, Albert Dweck, Javeria Tariq, Justin Olivera, Amanda Ghanie, Jorge Humberto Rodriguez-Quintero, Mara B. Antonoff, Brendon M. Stiles, Cecilia Pompili

This cross-sectional study examined gender representation in general thoracic surgery across 30 training programs in the United States and Europe (2023–2024). Women comprised 17.7 percent of faculty in US programs and 29.5 percent in European centers. Female representation in leadership was limited, with women serving as thoracic surgery program directors in 26.7 percent of US and 13 percent of European programs. While women were well represented among trainee society members (US: 39.2 percent, Europe: 46.1 percent), their proportion dropped significantly among active and senior members (US: 12.9 percent, Europe: 19.2 percent). The findings reveal persistent global disparities in women’s advancement to faculty and leadership roles, despite progress at the trainee levels. Barriers such as mentorship gaps and systemic biases hinder career progression. The authors call for targeted, collaborative strategies to foster diversity, equity, and inclusion. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Melanie Arnreiter, Moritz von Scheidt, Johannes M Albes, Tim Attmann, Andreas Boening, Yeong-Hoon Choi, Lenard Conradi, Bernhard C Danner, Andreas Fach, Ivar Friedrich, Herko Grubitzsch, Roland Heck, Alexander Joost, Christoph Knosalla, Martin Misfeld, Martin Oberhoffer, Julia Riebandt, Andreas Schaefer, Matthias Siepe, Thomas Walther, Gerhard Wimmer-Greinecker, Uwe Zeymer, Heribert Schunkert, Adnan Kastrati, Sigrid Sandner

This article highlights the results from the Ticagrelor in CABG (TiCAB) trial, which examined the use of Ticagrelor monotherapy in coronary artery bypass grafting (CABG) compared to aspirin. This study involved 752 patients. The authors found no significant difference in major adverse cardiac and cerebrovascular events (MACCE) between the aspirin and Ticagrelor groups, even when stratified for different complexity levels of coronary disease based on SYNTAX scores. 

Source: The Annals of Thoracic Surgery
Author(s): Chun-Hung Ho, Chia-Pin Lin, Feng-Cheng Chang, Chun-Yu Chen, Yu-Ting Cheng, Ying-Chang Tung, Yi-Hsin Chan, Victor Chien-Chia Wu, Pao-Hsien Chu, Shao-Wei Chen

This study evaluated the long-term effects of blood pressure (BP) and heart rate (HR) on 839 patients post-surgical repair of acute type A aortic dissection. Key findings showed that a systolic BP over 150 mm HG at discharge correlated with increased mortality. An HR of 81 to 100 beats per minute was linked to higher overall mortality, while an HR over 100 beats per minute raised both mortality and aortic surgery event risk. This study illustrates the fact that effective management of BP and HR is crucial for better long-term outcomes.  

Source: Interdisciplinary Cardiovascular and Thoracic Surgery
Author(s): Alba M. Fernandez Gonzalez, Jose R. Matilla, Orsolya Anna Pipek, Laura Gonzalez Sanchez, Merjem Begic, Zsolt Megyesfalvi, Balazs Döme, Clemens Aigner

This retrospective single-center study analyzed 143 patients who underwent chest wall resection and reconstruction from 2010–2023. Among these, 55.2 percent had lung cancer invading the chest wall, predominantly adenocarcinoma and squamous cell carcinoma. Rib resection alone was performed in 69.9 percent of cases, with reconstruction utilizing synthetic, metallic, or combined materials, often alongside muscle or myocutaneous flaps. R0 resection was achieved in 85.9 percent of cases. The median tumor size was 10 cm. Perioperative complications occurred in 25.7 percent, associated with factors such as age, sternal resection, and longer surgery duration. Neuropathic pain was more frequent after posterolateral thoracotomy. The median disease-free survival was 36 months, and the median overall survival was 80 months, with a five-year overall survival of 74.1 percent. The type of reconstruction did not affect survival or the incidence of complications. Reduced survival was linked to older age, squamous histology, larger resections, postoperative complications, and poor postoperative performance status. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Yeke Huang, Xipeng Wang, Yajie Zhang, Yuqin Cao, Yunjiu Gou, Shumin Wang, Hecheng Li

This multicenter retrospective study compared video-assisted thoracic surgery (VATS) and robot-assisted thoracic surgery (RATS) for anterior mediastinal lesions in 1,076 patients across three Chinese centers. Utilizing propensity score matching, researchers found that with the lateral thoracic approach, RATS demonstrated shorter catheter retention, reduced postoperative stays, and lower complication rates. However, with the subxiphoid approach, RATS resulted in higher drainage volume and longer catheter retention. The study concludes that the choice of surgical approach significantly impacts outcomes, with RATS being more beneficial for lateral thoracic cases. 

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