An interesting case series of cardiotoxicity of modern chemotherapy attempting to elucidate mechanisms of heart failure.
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Cancer
November 1, 2016
August 26, 2015
Investigators from Stanford developed a nine-gene expression predictor for survival outcome in early-stage nonsquamous NSCLC. They developed and validated a quantitative real-time polymerase chain reaction assay easily applicable to routinely obtained paraffin-embedded tumor specimens.
June 16, 2015
Data from a variety of US sources were used to estimate the contribution of smoking to mortality for 12 common malignancies (colorectal, esophagus, kidney, larynx, liver, lung, leukemia, head/neck, pancreas, stomach, bladder, cervix. The contribution of smoking to mortality ranged from 10% (colorectal) to 77% (larynx). The overall contribution was
April 13, 2015
This retrospective case-control study involving 1852 Hodgkin lymphoma 5-year survivors found that radiation to the heart valves tend to increase the risk for clinically significant valvular heart disease. The rate increased 3.1-fold in patients receiving 31-35 Gy and 11.8-fold in those who received > 40 Gy.
December 18, 2014
This randomized trial in New Zealand assigned smokers who wished to quit to either nicotrine replacement therapy or cytisine therapy.
June 25, 2014
In this study presented by Dr. Joshua A. Roth recently at the ASCO meeting, they used a model to forecast the 5-year results of implementation of a screening program (as suggest the NLST, age older than 55 with at least 30 pack-years of smoking history) in comparison to no screening program.
Transcriptomic Architecture of the Adjacent Airway Field Cancerization in Non–Small Cell Lung Cancer
April 14, 2014
In this promising investigation, authors have found changes associated with airway cancerization in large airways in lung cancer patients, while these changes are absent in cancer-free smokers. And in addition, with shorter distance from tumors, airway cancerization expression increases statistically.