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Heart Failure - Ischemic

Timing of Coronary Artery Bypass Grafting After Acute Myocardial Infarction May Not Influence Mortality and Readmissions
June 15, 2021
Fascinating confirmation of null hypotheses including bleeding complications and survival in a Pennsylvanian cohort study, despite the easily predictable previous PCI, hock, and IABP prevalence in the emergency group. The statistical model is elaborate and complex. Perhaps a randomized trial could now be justified!
Reverse Remodeling With Left Ventricular Assist Devices
May 25, 2021
An authoritative, scholarly but very readable review of the evolution of mechanical circulatory support of the left ventricle from the non-surgical standpoint.
A Comprehensive Deep-Dive on Secondary Mitral Regurgitation
April 15, 2021
In the special April issue of JACC Imaging focusing on secondary mitral regurgitation (SMR), a number of articles on outcomes after transcatheter edge-to-edge repair (TEER) are reported. Specifically, the concept of proportionate vs disproportionate SMR was explored.
Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery: A Meta-Analysis
October 26, 2020
Within the limitations of a meta-analysis, a useful work advancing that PCI may have a hitherto masked or hidden mortality
Dual Antiplatelet Therapy After Percutaneous Coronary Intervention and Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis
September 15, 2020
An open-access large metanalysis on the utility and risks of antiplatelets after PCI. Of note, mortality was not a primary endpoint. The message is that long dual antiplatelet use is an exchange between avoidance of myocardial events and serious bleeding. The novel oral anticoagulants may enter the arena soon..
Long-Term Outcomes in Patients With Severely Reduced Left Ventricular Ejection Fraction Undergoing Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting
May 13, 2020
This original article using very carefully the propensity match analysis tried to answer the question regarding long-term outcomes of patients with severely reduced left ventricular ejection fraction (LVEF) who undergo revascularization by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG).  
PCSK6-Mediated Regulation of Vascular Remodeling
March 1, 2020
A very easy-to-read editorial that digests a manuscript on the IMPROVE study.
American Association for Thoracic Surgery/International Society for Heart and Lung Transplantation Guidelines on Selected Topics in Mechanical Circulatory Support
January 30, 2020
The American Association for Thoracic Surgery and International Society for Heart and Lung Transplantation provide a consensus guidelines document on ten important aspects in mechanical circulatory support.  These include:
Percutaneous Coronary Angioplasty Versus Coronary Artery Bypass Grafting in Treatment of Unprotected Left Main Stenosis (NOBLE): A Prospective, Randomised, Open-Label, Non-Inferiority Trial
January 10, 2020
''CABG was significantly better than PCI (p=0·0066........''
New Antihyperglycemic Medications With Cardiovascular Protection for Patients With Diabetes: What do Surgeons Need to Know?
November 11, 2019
A useful narrative on pharmacology and metabolomics for surgeons caring for the diabetic population; the vast majority of the CTSNet membership.

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