Clinical Epidemiology

JANS Article

Editor’s Choice – Trends in Management and Outcomes of Type B Aortic Dissection: A Report From the International Registry of Aortic Dissection

December 11, 2023 | Aristotle ProtopapasGold Commentor

Interesting registry review form an international voluntary registry. The retrospective historical data can be juxtaposed favourably to the recently presented ( also excellent results) in JANS on acute dissection in Denmark from a compulsory national...

JANS Article

Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years

November 29, 2023 | Aristotle ProtopapasGold Commentor

An important free-access report on the PARTNER 3 trial that discusses the TAVI-first policy in patietns with Society of Thoracic Surgeons Predicted Risk of Mortality risk less than 4% (...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Long Term Health Related Quality of Life After Acute Type B Aortic Dissection: A Cross Sectional Survey Study

September 12, 2023 | Aristotle ProtopapasGold Commentor

This free-access report raises a number of research questions in light of a relatively unsatisfactory response of 55 percent that may reflect unrecorded deaths and should be addressed in future...

JANS Article

Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes

August 31, 2023 | Aristotle ProtopapasGold Commentor

This is an open access genomic study of carotid atheroma in Viennese patients with a useful extensive discussion on potential translational value of the signature of calcification, juxtaposed to sonographic...

JANS Article

Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts

September 20, 2022 | Aristotle ProtopapasGold Commentor

Plasma metabolomic profiles were examined to determine differences in social determinants of health between Black and white women. This observational study paves the groundwork for further investigation of social disparity...

JANS Article

Treatment of Carotid Stenosis in Asymptomatic, Nonoctogenarian, Standard Risk Patients with Stenting Versus Endarterectomy Trials

July 1, 2022 | Aristotle ProtopapasGold Commentor

This is an interesting, well-written account of pooled results of two medium-size RCTs . It would be interesting to see a third arm of optimum medical therapy in follow-up studies...

JANS Article

Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association

June 23, 2022 | Aristotle ProtopapasGold Commentor

This scientific statement is a granular contribution to a major cardiovascular issue, illuminating nuances of the “generally recognized as safe” (GRAS) FDA designation. One would expect the relevant Thoracic Associations...

JANS Article

Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer

May 26, 2022 | Aristotle ProtopapasGold Commentor

No statistical significance ,between the two arms, regarding the OVERALL survival in this RCT funded by the supplier and manufacturer of the immunotherapy in question….

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JANS Article

Heart Failure and Atrial Fibrillation—Chicken or Egg?

April 5, 2022 | Aristotle ProtopapasGold Commentor

A brief but comprehensive editorial on nuances of the links between atrial fibrillation and heart failure, apropos a trial we have commented recently on, by the Johns Hopkins team that...

JANS Article

Social Determinants of Cardiovascular Disease

March 4, 2022 | Aristotle ProtopapasGold Commentor

A paper that addresses a gap in knowledge and will guide future research: of particular interest, the penultimate paragraph on The Role of Interventions.

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JANS Article

Management of Abdominal Aortic Aneurysms

November 1, 2021 | Aristotle ProtopapasGold Commentor

An extremely useful and free-access update on a major vascular entity. The ‘Areas of Uncertainty’ is a particularly useful chapter, discussing the available technology and its current supra-renal limitations and...

JANS Article

Commentary: Strategic surgery to type A dissection: A bird in the hand or 2 in the bush?

October 22, 2021 | Aristotle ProtopapasGold Commentor

A brief focused commentary on a recent medium size Japanese series of succesful surgery for Acute Aortic Syndrome. The limitations of the series presented in well- written Uchida manuscript( and...

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