Clinical Epidemiology

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the notion of varied aetiologies of...

JANS Article

Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years

November 29, 2023 | Aristotle ProtopapasGold Commentor

An important free-access report on the PARTNER 3 trial that discusses the TAVI-first policy in patietns with Society of Thoracic Surgeons Predicted Risk of Mortality risk less than 4% (...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Long Term Health Related Quality of Life After Acute Type B Aortic Dissection: A Cross Sectional Survey Study

September 12, 2023 | Aristotle ProtopapasGold Commentor

This free-access report raises a number of research questions in light of a relatively unsatisfactory response of 55 percent that may reflect unrecorded deaths and should be addressed in future...

JANS Article

Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes

August 31, 2023 | Aristotle ProtopapasGold Commentor

This is an open access genomic study of carotid atheroma in Viennese patients with a useful extensive discussion on potential translational value of the signature of calcification, juxtaposed to sonographic...

JANS Article

Cardiac Myosin Activation With Omecamtiv Mecarbil in Systolic Heart Failure

November 17, 2020 | Aristotle ProtopapasGold Commentor

A latge RCT of the first myosin inhibitor in severe chronic heart failure: somewhat difficult to interpret results, as deaths were slightly higher in the intervention group while there was...

JANS Article

Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery: A Meta-Analysis

October 26, 2020 | Aristotle ProtopapasGold Commentor

Within the limitations of a meta-analysis, a useful work advancing that PCI may have a hitherto masked or hidden mortality

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JANS Article

Place and Causes of Acute Cardiovascular Mortality During the COVID-19 Pandemic

October 4, 2020 | Aristotle ProtopapasGold Commentor

The authors are concerned about the ‘deaths at home’ having the greatest contribution to the excess of acute cardiovascular deaths in that period of the recent epidemic, AND LOCKDOWN in...

JANS Article

Reassessing the Operative Threshold for Abdominal Aortic Aneurysm Repair in the Context of COVID-19

September 7, 2020 | Aristotle ProtopapasGold Commentor

Patients with aneurysms 7 cm or greater demonstrated a higher probability of survival when treated immediately, compared to delayed repair, for patients under 80 years of age. An interesting attempt...

JANS Article

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases

May 23, 2020 | Aristotle ProtopapasGold Commentor

a readable review that advances the position that Adolphe Quetelet’s formula is now clinically obsolete

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JANS Article

Graduated Compression Stockings as Adjuvant to Pharmaco-Thromboprophylaxis in Elective Surgical Patients (GAPS Study): Randomised Controlled Trial

May 15, 2020 | Aristotle ProtopapasGold Commentor

A medium-sized RCT from the Imperial College. The research question are of interest for all cardiovascular, thoracic, and general surgeons as well as all healthcare professionals.

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JANS Article

The 2020 Update of the CEAP Classification System and Reporting Standards

May 6, 2020 | Aristotle ProtopapasGold Commentor

Use of anatomic abbreviations instead of numbers seems pro-intuitive …

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JANS Article

Empty Non-Coronavirus Beds Raise Fears That Sickest Are Avoiding NHS

April 13, 2020 | Aristotle ProtopapasGold Commentor

Topical review on the epidemic in Britain, with a number of observations that relate to the cardiothoracic surgeons and all healthcare professionals: -The assertion that the National Health Service in...

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