Coronary Disease - PCI

JANS Article

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Unprotected Left Main Stenosis: 10-Year Final Results From the Randomised, Open-Label, Non-Inferiority NOBLE Trial

May 13, 2026 | Vincent SierGold Contributor

In this article, the authors report the 10-year final results of the NOBLE trial comparing percutaneous coronary intervention (PCI) with newer generation drug–eluting stents vs coronary artery bypass grafting (CABG) for unprotected left main coronary...

JANS Article

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Unprotected Left Main Stenosis: 10-Year Final Results From the Randomised, Open-Label, Non-Inferiority NOBLE Trial

May 13, 2026 | Vincent SierGold Contributor

In this article, the authors report the 10-year final results of the NOBLE trial comparing percutaneous coronary intervention (PCI) with newer generation drug–eluting stents vs coronary artery bypass grafting (CABG)...

JANS Article

Spontaneous Myocardial Infarction After Left Main Revascularization: The EXCEL Trial

March 26, 2026 | Vincent SierGold Contributor

In this pre-specified analysis of the EXCEL trial, 1,882 patients with left main disease underwent percutaneous coronary intervention (PCI) (n=952) or coronary artery bypass grafting (CABG) (n=930). At five years,...

JANS Article

Percutaneous vs. Surgical Revascularization of Non-ST-Segment Elevation Myocardial Infarction With Multivessel Disease: The SWEDEHEART Registry

March 6, 2025 | Mateo Marin-CuartasGold Contributor

The debate continues over long-term outcomes of percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease. This study,...

JANS Article

Commentary: What Matters More—Method of Revascularization or Completeness?

April 24, 2024 | Mujtaba MubashirGold Contributor

This commentary succinctly reviews the 2021 coronary revascularization and the 2023 chronic coronary disease guidelines with relation to use of PCI and CABG in patients with ischemic cardiomyopathy and ejection...

JANS Article

COVID‐19: The Rising Cost of Cardiac Surgery and Disease

December 4, 2020 | Aristotle ProtopapasGold ContributorGold Commentor

A brief and readable editorial on the United Kingdom prespective on the global impact of the pandemic to the delivery of cardiovascular care, attempting a semi-quantitative economic appraisal of the...

JANS Article

Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery: A Meta-Analysis

October 26, 2020 | Aristotle ProtopapasGold ContributorGold Commentor

Within the limitations of a meta-analysis, a useful work advancing that PCI may have a hitherto masked or hidden mortality

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JANS Article

Implications of Alternative Definitions of Peri-Procedural Myocardial Infarction After Coronary Revascularization

October 12, 2020 | Aristotle ProtopapasGold ContributorGold Commentor

An analysis, from the cardiology viewpoint, of the MI nomenclature issues around the external validity of the EXCEL trial that undermined the EACTS support of the relevant 2018 guidelines

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JANS Article

Dual Antiplatelet Therapy After Percutaneous Coronary Intervention and Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis

September 15, 2020 | Aristotle ProtopapasGold ContributorGold Commentor

An open-access large metanalysis on the utility and risks of antiplatelets after PCI. Of note, mortality was not a primary endpoint. The message is that long dual antiplatelet use is...

JANS Article

Initial Invasive or Conservative Strategy for Stable Coronary Disease

April 3, 2020 | Wei-Guo MaGold Contributor

In the ISCHEMIA Trial, 5179 patients with moderate or severe myocardial ischemia were randomized equally into two groups based on initial management strategy: initial invasive strategy (angiography and revascularization when...

JANS Article

Percutaneous Coronary Angioplasty Versus Coronary Artery Bypass Grafting in Treatment of Unprotected Left Main Stenosis (NOBLE): A Prospective, Randomised, Open-Label, Non-Inferiority Trial

January 10, 2020 | Aristotle ProtopapasGold ContributorGold Commentor

‘CABG was significantly better than PCI (p=0·0066……..”

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JANS Article

The Discussion Continues as the EXCEL Authors Respond to EACTS’s Withdrawal of Support of the LMS Chapter of the EACTS/ESC Revascularization Guidelines

December 19, 2019 | Joel DunningGold ContributorSilver Commentor

Following the withdrawal of the support of EACTS for the left main stem chapter of the EACTS/ESC Chapter of the revascularisation guidelines following the BBC Newsnight documentary of this, and...

JANS Article

Inflammation as a Treatment Target After Acute Myocardial Infarction

November 18, 2019 | Aristotle ProtopapasGold ContributorGold Commentor

An editorial related to a recent randomized controlled trial suggesting a striking benefit of anti-inflammatory secondary prevention after recent myocardial events.

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