Heart Failure - Ischemic

JANS Article

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

August 30, 2024 | Aristotle ProtopapasGold Commentor

An experiment that may find some translational value in the drive to elucidate inflammation as a target for controlling cardiovascular disease. Columbia University has on this occasion focused on elucidating by flow cytometry the nuances...

JANS Article

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

August 30, 2024 | Aristotle ProtopapasGold Commentor

An experiment that may find some translational value in the drive to elucidate inflammation as a target for controlling cardiovascular disease. Columbia University has on this occasion focused on elucidating...

JANS Article

Mechanical Circulatory Support in Cardiogenic Shock — Persistence and Progress

May 18, 2024 | Aristotle ProtopapasGold Commentor

This article presents a succinct but comprehensive expert viewpoint on support in cardiogenic shock using the manuscript of the DanGer trial on promising results of Impella in a highly selected...

JANS Article

Coronary Plaque Sampling Reveals Molecular Insights Into Coronary Artery Disease

August 7, 2023 | Aristotle ProtopapasGold Commentor

In a research letter on a small pilot genomic study of sampling coronary atheroma, the authors offer a brief explanation on how their technique can be applied to detect stability...

JANS Article

Five-Year Follow-Up after Transcatheter Repair of Secondary Mitral Regurgitation

June 1, 2023 | Aristotle ProtopapasGold Commentor

This five-year follow-up of a large randomized controlled clinical trial on outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation, as compared with outcomes after maximal doses of guideline-directed medical...

JANS Article

A Comprehensive Deep-Dive on Secondary Mitral Regurgitation

April 15, 2021 | Gilbert Tang

In the special April issue of JACC Imaging focusing on secondary mitral regurgitation (SMR), a number of articles on outcomes after transcatheter edge-to-edge repair (TEER) are reported. Specifically, the concept...

JANS Article

Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery: A Meta-Analysis

October 26, 2020 | Aristotle ProtopapasGold Commentor

Within the limitations of a meta-analysis, a useful work advancing that PCI may have a hitherto masked or hidden mortality

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JANS Article

Dual Antiplatelet Therapy After Percutaneous Coronary Intervention and Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis

September 15, 2020 | Aristotle ProtopapasGold Commentor

An open-access large metanalysis on the utility and risks of antiplatelets after PCI. Of note, mortality was not a primary endpoint. The message is that long dual antiplatelet use is...

JANS Article

Long-Term Outcomes in Patients With Severely Reduced Left Ventricular Ejection Fraction Undergoing Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting

May 13, 2020 | Thomas Theologou

This original article using very carefully the propensity match analysis tried to answer the question regarding long-term outcomes of patients with severely reduced left ventricular ejection fraction (LVEF) who undergo...

JANS Article

PCSK6-Mediated Regulation of Vascular Remodeling

March 1, 2020 | Aristotle ProtopapasGold Commentor

A very easy-to-read editorial that digests a manuscript on the IMPROVE study. The study suggests an association of this group of enzymes to the Matrix Metalloproteinases and hence a theory...

JANS Article

American Association for Thoracic Surgery/International Society for Heart and Lung Transplantation Guidelines on Selected Topics in Mechanical Circulatory Support

January 30, 2020 | Wei-Guo Ma

The American Association for Thoracic Surgery and International Society for Heart and Lung Transplantation provide a consensus guidelines document on ten important aspects in mechanical circulatory support. These include: 1....

JANS Article

Percutaneous Coronary Angioplasty Versus Coronary Artery Bypass Grafting in Treatment of Unprotected Left Main Stenosis (NOBLE): A Prospective, Randomised, Open-Label, Non-Inferiority Trial

January 10, 2020 | Aristotle ProtopapasGold Commentor

‘CABG was significantly better than PCI (p=0·0066……..”

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JANS Article

New Antihyperglycemic Medications With Cardiovascular Protection for Patients With Diabetes: What do Surgeons Need to Know?

November 11, 2019 | Aristotle ProtopapasGold Commentor

A useful narrative on pharmacology and metabolomics for surgeons caring for the diabetic population; the vast majority of the CTSNet membership.

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