Heart Failure - Nonischemic

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the notion of varied aetiologies of...

JANS Article

Five-Year Follow-Up after Transcatheter Repair of Secondary Mitral Regurgitation

June 1, 2023 | Aristotle ProtopapasGold Commentor

This five-year follow-up of a large randomized controlled clinical trial on outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation, as compared with outcomes after maximal doses of guideline-directed medical...

JANS Article

Mapping Human Cardiac Sarcoidosis by Single Nuclear and Spatial Profiling

September 30, 2022 | Aristotle ProtopapasGold Commentor

This editorial describes the evolving pathway of diagnosing a disease that is predicted to augment the indication for orthotopic cardiac transplantation. Cardiac involvement of sarcoidosis accounts for the majority of...

JANS Article

Effects of Atrial Fibrillation on the Human Ventricle

February 24, 2022 | Aristotle ProtopapasGold Commentor

Interesting study of hypertrophied human cardiomyocytes

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JANS Article

The Right Ventricle During Veno-Venous Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: Can We Protect the Injured Ventricle?

January 21, 2022 | Aristotle ProtopapasGold Commentor

An editorial with some interest for the cardiothoracic surgeon, in particular the awareness of changes in the right vantricle during ECMO support , mostly drawn from the recent Covid experiences,...

JANS Article

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

November 19, 2021 | Aristotle ProtopapasGold Commentor

Impressive decrease of death (by approximaltely 40% !) in 2 years from a small RCT in elective structural heart surgery for degeneration. The assumption is a benefit by improvement in...

JANS Article

Echocardiography in Weaning Right Ventricular Mechanical Circulatory Support: are we measuring the right stuff?

October 10, 2021 | Aristotle ProtopapasGold Commentor

Scholarly endeavour to digest, in a relatively short and dense manuscript, the State-of-the-Art in assessing the function of the Forgotten Chamber. The notion of surgjcal pericardiotomy as a confounder of...

JANS Article

Defining Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome

October 1, 2021 | Aristotle ProtopapasGold Commentor

A scholarly narrative on the utility of quantifying the performance of the right ventricle: the RV has been hitherto empirically assessed in many clinical setups.

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JANS Article

Reverse Remodeling With Left Ventricular Assist Devices

May 25, 2021 | Aristotle ProtopapasGold Commentor

An authoritative, scholarly but very readable review of the evolution of mechanical circulatory support of the left ventricle from the non-surgical standpoint.

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JANS Article

A Comprehensive Deep-Dive on Secondary Mitral Regurgitation

April 15, 2021 | Gilbert Tang

In the special April issue of JACC Imaging focusing on secondary mitral regurgitation (SMR), a number of articles on outcomes after transcatheter edge-to-edge repair (TEER) are reported. Specifically, the concept...

JANS Article

Early Rhythm-Control Therapy in Patients With Atrial Fibrillation

October 1, 2020 | Aristotle ProtopapasGold Commentor

Death from cardiovascular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome was reduced (P=0.005) by early pharmacogical or inteventional ablation for fast response-atrial fibrillation in...

JANS Article

Graduated Compression Stockings as Adjuvant to Pharmaco-Thromboprophylaxis in Elective Surgical Patients (GAPS Study): Randomised Controlled Trial

May 15, 2020 | Aristotle ProtopapasGold Commentor

A medium-sized RCT from the Imperial College. The research question are of interest for all cardiovascular, thoracic, and general surgeons as well as all healthcare professionals.

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JANS Article

A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse

May 11, 2020 | Aristotle ProtopapasGold Commentor

Interesting hypothesis in a rodent model of myxomatous degeneration.

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