Pharmacology

JANS Article

Paclitaxel coated devices (PCD) used in the treatment of peripheral arterial disease: update to previous MHRA guidance on use. Where indicated, PCD can be considered as a treatment option for both critical limb ischaemia (CLI) and intermittent claudicatio

February 12, 2024 | Aristotle ProtopapasGold Commentor

Level IV evidence from the Broitish government in the most prominent debate on cardiovascular pharmacology of the last few years: Since December 2018, the paclitaxel coated devices have been scrutinised for safety . This week’s...

JANS Article

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

January 23, 2024 | Aristotle ProtopapasGold Commentor

This is a useful manuscript on long-term follow up confirming the findings of the five-year study, with regards to superior survival on CRT than on ICD. The authors discuss the...

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association

June 23, 2022 | Aristotle ProtopapasGold Commentor

This scientific statement is a granular contribution to a major cardiovascular issue, illuminating nuances of the “generally recognized as safe” (GRAS) FDA designation. One would expect the relevant Thoracic Associations...

JANS Article

Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer

May 26, 2022 | Aristotle ProtopapasGold Commentor

No statistical significance ,between the two arms, regarding the OVERALL survival in this RCT funded by the supplier and manufacturer of the immunotherapy in question….

...
JANS Article

Heart Failure and Atrial Fibrillation—Chicken or Egg?

April 5, 2022 | Aristotle ProtopapasGold Commentor

A brief but comprehensive editorial on nuances of the links between atrial fibrillation and heart failure, apropos a trial we have commented recently on, by the Johns Hopkins team that...

JANS Article

Social Determinants of Cardiovascular Disease

March 4, 2022 | Aristotle ProtopapasGold Commentor

A paper that addresses a gap in knowledge and will guide future research: of particular interest, the penultimate paragraph on The Role of Interventions.

...
JANS Article

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

November 9, 2021 | Aristotle ProtopapasGold Commentor

A good-size Terumo-sponsored RCT that is set to impact on decisions to discontinue DAPT early after PCI with absorbable stent, a change that will somehow decrease the surgical risk of...

JANS Article

Management of Abdominal Aortic Aneurysms

November 1, 2021 | Aristotle ProtopapasGold Commentor

An extremely useful and free-access update on a major vascular entity. The ‘Areas of Uncertainty’ is a particularly useful chapter, discussing the available technology and its current supra-renal limitations and...

JANS Article

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

October 21, 2021 | Aristotle ProtopapasGold Commentor

A large randomised double-blinded trial reporting a considerable benefit ( 0.79 HR with very small p and supporting confidence intervals) of the Boehringer SGLPT-2 inhibitor regardless of presence of formal...

JANS Article

2021 The American Association for Thoracic Surgery expert consensus document: Surgical treatment of acute type A aortic dissection

September 24, 2021 | Aristotle ProtopapasGold Commentor

A comprehensive update on the evidence on the management of acute aortic syndromes, including IMH. Of particular interest is the robust recommendation to bypass non-dedicated aortic centers even to the...

JANS Article

Commentary: Cardioplegia in complex root surgery for adults: Many solutions, but does it really matter?

September 13, 2021 | Aristotle ProtopapasGold Commentor

A brief but dense editorial included in a compedium on cardioplegia. The last sentence summarises what many colleagues would think on the matter of single-shot plegia for root surgery.

...
LOAD MORE
ADVERTISE ON CTSNET