Pharmacology

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how to target the behavior of...

JANS Article

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

January 23, 2024 | Aristotle ProtopapasGold Commentor

This is a useful manuscript on long-term follow up confirming the findings of the five-year study, with regards to superior survival on CRT than on ICD. The authors discuss the...

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association

June 23, 2022 | Aristotle ProtopapasGold Commentor

This scientific statement is a granular contribution to a major cardiovascular issue, illuminating nuances of the “generally recognized as safe” (GRAS) FDA designation. One would expect the relevant Thoracic Associations...

JANS Article

Dual Antiplatelet Therapy After Percutaneous Coronary Intervention and Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis

September 15, 2020 | Aristotle ProtopapasGold Commentor

An open-access large metanalysis on the utility and risks of antiplatelets after PCI. Of note, mortality was not a primary endpoint. The message is that long dual antiplatelet use is...

JANS Article

Combined Antiplatelet/Anticoagulant Drug for Cardiac Ischemia/Reperfusion Injury

August 18, 2020 | Aristotle ProtopapasGold Commentor

A review that may affect pharma strategy in the immediate future.

...
JANS Article

A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse

May 11, 2020 | Aristotle ProtopapasGold Commentor

Interesting hypothesis in a rodent model of myxomatous degeneration.

...
JANS Article

PCSK6-Mediated Regulation of Vascular Remodeling

March 1, 2020 | Aristotle ProtopapasGold Commentor

A very easy-to-read editorial that digests a manuscript on the IMPROVE study. The study suggests an association of this group of enzymes to the Matrix Metalloproteinases and hence a theory...

JANS Article

Eating Chocolate to Improve Muscle Health and Walking Ability in Patients With Peripheral Artery Disease

February 20, 2020 | Aristotle ProtopapasGold Commentor

The authors revisit the older, somewhat misinterpreted hypothesis of cocoa and vasodilation. The title may again be misinterpreted by the general media as an encouragement to gorge on HIGH CALORIE,...

JANS Article

Reduced Leaflet Motion After Transcatheter Aortic Valve Replacement

November 22, 2019 | Aristotle ProtopapasGold Commentor

Puzzling subgroup from the GALILEO trial, which appears in the same issue of the periodical as an article that discredits the use of rivaroxaban as thromboprevention strategy : https://www.nejm.org/doi/full/10.1056/NEJMoa1911425?query=recirc_curatedRelated_article, And...

JANS Article

Inflammation as a Treatment Target After Acute Myocardial Infarction

November 18, 2019 | Aristotle ProtopapasGold Commentor

An editorial related to a recent randomized controlled trial suggesting a striking benefit of anti-inflammatory secondary prevention after recent myocardial events.

...
JANS Article

New Antihyperglycemic Medications With Cardiovascular Protection for Patients With Diabetes: What do Surgeons Need to Know?

November 11, 2019 | Aristotle ProtopapasGold Commentor

A useful narrative on pharmacology and metabolomics for surgeons caring for the diabetic population; the vast majority of the CTSNet membership.

...
LOAD MORE
ADVERTISE ON CTSNET