Pharmacology

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the notion of varied aetiologies of...

JANS Article

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

January 23, 2024 | Aristotle ProtopapasGold Commentor

This is a useful manuscript on long-term follow up confirming the findings of the five-year study, with regards to superior survival on CRT than on ICD. The authors discuss the...

JANS Article

Shear Force-Induced Platelet Clearance is a New Mechanism of Thrombocytopenia

November 6, 2023 | Aristotle ProtopapasGold Commentor

The clinical problem addressed in this study is bleeding in patients who undergo ECMO. The authors endeavor to address the issue through a quantitative cohort study by reflecting on how...

JANS Article

Heart Failure with Preserved Ejection Fraction — A Metabolic Disease?

September 21, 2023 | Aristotle ProtopapasGold Commentor

Professor Pinto raises, in this editorial, a number of important points with regards to heart failure. Starting from a succinct definition of classification by ejection fraction, proceeds to analyse the...

JANS Article

Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association

June 23, 2022 | Aristotle ProtopapasGold Commentor

This scientific statement is a granular contribution to a major cardiovascular issue, illuminating nuances of the “generally recognized as safe” (GRAS) FDA designation. One would expect the relevant Thoracic Associations...

JANS Article

Antithrombotic Treatment After Coronary Artery Bypass Graft Surgery: Systematic Review and Network Meta-Analysis

October 11, 2019 | Benjamin Bidstrup

This timely review examines the use of single and mutiple agents to decrease saphenous graft failure after CABG. These are difficult and expensive studies to perform, requiring repeat imaging after...

JANS Article

Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report

September 5, 2019 | Aristotle ProtopapasGold Commentor

The January update of an expert panel from the American College of Chest Physicians on the expanding clinical entity of pulmonary hypertension, especially pertinent to the transplant community.

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JANS Article

Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients With Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

August 29, 2019 | Aristotle ProtopapasGold Commentor

An interesting meta-analysis discouraging perhaps the use of this KATP modulator, especially after surgical revascularization where optimization of serum potassium is generally sought.

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JANS Article

Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant

August 19, 2019 | Mark FergusonBronze Contributor

A standardized perioperative management protocol for pts taking direct oral anticoagulants for atrial fibrillation entailed no bridging with other anticoagulants. It resulted in low and acceptable rates of major bleeding...

JANS Article

In Global News: Surgery in Conflict Zones, Making Blood Type O, and Spinning Views on Treatments

June 21, 2019 | Claire Vernon

Patient Care and General Interest A father got a sternotomy scar tattoo in support of his son after the boy underwent surgery for supravalvular aortic stenosis. In a Viewpoint paper...

JANS Article

Targeting MAPK Phosphorylation of Connexin43 Provides Neuroprotection in Stroke

March 15, 2019 | Wei-Guo Ma

Researchers from the University of British Columbia, Seattle and Belgium successfully used a new approach that significantly minimized brain damage caused by ischemic stroke in mouse models. The new approach...

JANS Article

Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease

March 15, 2019 | Aristotle ProtopapasGold Commentor

Very useful open access review, especially the simple figure on page 959.

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JANS Article

β-Adrenergic Agonist Albuterol Improves Pulmonary Vascular Reserve in Heart Failure With Preserved Ejection Fraction: A Randomized Controlled Trial

November 9, 2018 | Aristotle ProtopapasGold Commentor

Interesting small randomized controlled trial that will definitely be widely discussed.

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