Diagnostic Yield and Synergistic Impact of Needle Aspiration and Forceps Biopsy With Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions (CONFIDENT-ENB)

This randomized crossover trial evaluated whether combining needle aspiration and forceps biopsy improves diagnostic yield compared to using a single device alone during electromagnetic navigation bronchoscopy (ENB) for peripheral pulmonary lesions. A total of 142 participants underwent both biopsy methods sequentially under moderate sedation. The primary outcome was the diagnostic yield, defined as the percentage of patients whose biopsy provided a specific diagnosis.  Results showed that the combined approach yielded a diagnostic success rate of 66.9 percent, which was significantly higher than either forceps biopsy (44.4 percent) or needle aspiration (51.4 percent) alone (p