Effect of Fenoldopam on Use of Renal Replacement Therapy Among Patients With Acute Kidney Injury After Cardiac Surgery

This randomized double-blind multicenter study involving 667 pts evaluated the utility of IV fenoldopam in reducing the rate of renal replacement therapy for patients undergoing cardiac surgery who exhibit postoperative acute kidney injury.  Fenoldopam did not importantly reduce the need for renal replacement therapy or 30 day mortality.  Its use was asssociated with an increase in postoperative hypotension.