Immunosenescence Biomarkers and Outcomes in Isolated Coronary Artery Bypass Grafting

This retrospective cohort study of 9,046 patients evaluated the prognostic utility of preoperative immunosenescence biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), on the outcomes following isolated coronary artery bypass grafting (CABG). Utilizing multivariable and Cox regression analysis of data spanning 2010 to 2025, researchers identified that elevated baseline inflammatory indices were independently associated with significantly higher 30-day perioperative mortality (p