The authors compared mechanically expanded TAVR to self-expanding TAVR in a randomized non-inferiority trial. Major adverse events occurred in 20% and 17% of patients, respectively (safety measure). The one-year rates of mortality, stroke, or paravalvular leak for the valves were 15.4% and 25.5%, respectively (effectiveness measure). Mechanically expanded valves are not inferior to self-expanding valves and broaden the options available for high risk patients.
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Mechanically Expanded Versus Self-Expanding Transcatheter Aortic Valve Replacement
Submitted by: Mark Ferguson
Source: JAMA
Keywords:
Author(s): Ted E. Feldman, Michael J. Reardon, Vivek Rajagopal, Raj R. Makkar, Tanvir K. Bajwa, Neal S. Kleiman, Axel Linke, Dean J. Kereiakes, Ron Waksman, Vinod H. Thourani, Robert C. Stoler, Gregory J. Mishkel, David G. Rizik, Vijay S. Iyer, Thomas G. Gleason, Didier Tchétché, Joshua D. Rovin, Maurice Buchbinder, Ian T. Meredith, Matthias Götberg, Henrik Bjursten, Christopher Meduri, Michael H. Salinger, Dominic J. Allocco, Keith D. Dawkins
